Description

L-Methionine-13C5,15N, n-Fmoc, n-(9-Fluorenylmethoxycarbonyl)-L-Methionine-13C5,15N is a stable isotope-labeled derivative of the essential amino acid methionine, specifically engineered for advanced research and analytical applications. This high-purity compound is critical for providing an internal standard in mass spectrometry, enabling precise quantification and metabolic pathway tracing in proteomics and metabolomics studies. It is an indispensable tool for pharmaceutical researchers, isotope labeling specialists, and analytical chemists working in drug discovery, biomarker validation, and nutritional science.

Application

• Mass Spectrometry Internal Standard: Used as a quantitative reference standard in LC-MS/MS and GC-MS for accurate measurement of methionine and related metabolites in complex biological matrices.
• Proteomics Research: Facilitates the study of protein synthesis, turnover, and post-translational modifications through stable isotope labeling techniques (SILAC).
• Metabolic Flux Analysis: Enables tracing of sulfur and methyl group metabolism in cell culture and in vivo studies to understand metabolic pathways.
• Pharmaceutical Development: Supports ADME (Absorption, Distribution, Metabolism, Excretion) studies and pharmacokinetic profiling of drug candidates.
• Peptide Synthesis: Serves as a protected, isotope-labeled building block for the solid-phase synthesis of peptides for research and diagnostic purposes.
• Nutritional Science: Used in tracer studies to investigate human and animal amino acid requirements, protein metabolism, and utilization.

Basic Information

Product Name	L-Methionine-13C5,15N, n-Fmoc, n-(9-Fluorenylmethoxycarbonyl)-L-Methionine-13C5,15N
CAS No.	1217437-64-3
Molecular Formula	C135H2115NO4S (Note: Formula reflects isotopic labeling)
Molecular Weight	Contact for details
Synonyms	Fmoc-L-Methionine-13C5,15N; (2S)-2-[(9H-Fluoren-9-ylmethoxy)carbonylamino]-4-(methylsulfanyl)-13C5,15N-butanoic acid; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-methionine-13C5,15N; Fmoc-Met-13C5,15N; Isotopically labeled Fmoc-methionine; 13C5,15N-Fmoc-Methionine; N-Fmoc-L-methionine (13C5, 15N)
EINECS	Contact for details

Quality Control

Every batch of L-Methionine-13C5,15N, n-Fmoc is produced and tested under strict quality management systems to ensure the highest isotopic and chemical purity for critical research applications. Our products undergo rigorous quality testing, including NMR, HPLC, and mass spectrometry, to ensure compliance with exacting research standards. Certificates of Analysis (COA) detailing isotopic enrichment, chemical purity, and analytical data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. This product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the vial to warm to room temperature in a desiccator before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 99 atom % 13C; ≥ 99 atom % 15N
Optical Rotation	Contact for details
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.