Description

(S)-1-(2,5-Difluorophenyl)Propan-1-Amine Hydrochloride CAS NO 1217437-41-6 is a high-purity chiral amine hydrochloride salt, serving as a critical building block in advanced organic synthesis. Its value lies in providing a stereochemically defined, fluorinated aromatic scaffold essential for constructing complex molecules with targeted biological activity. This compound is primarily needed by research and development teams in the pharmaceutical and agrochemical industries for applications such as medicinal chemistry, process development, and the synthesis of active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new drug candidates, particularly for central nervous system (CNS) and metabolic disease targets.
• Medicinal Chemistry: Used in structure-activity relationship (SAR) studies and lead optimization to explore the impact of fluorination and stereochemistry on potency and pharmacokinetics.
• Process Chemistry: Serves as a starting material or advanced intermediate in the scalable synthesis of active pharmaceutical ingredients (APIs) under Good Manufacturing Practice (GMP) conditions.
• Agrochemical Research: Employed in the development of novel herbicides, fungicides, and pesticides where the difluorophenyl moiety can enhance stability and bioavailability.
• Ligand and Catalyst Development: Utilized for the synthesis of chiral ligands and organocatalysts used in asymmetric synthesis.
• Reference Standard: Acts as a high-purity analytical standard for quality control and method validation in regulatory filings.

Basic Information

Product Name	(S)-1-(2,5-Difluorophenyl)Propan-1-Amine Hydrochloride
CAS No.	1217437-41-6
Molecular Formula	C9H10ClF2N
Molecular Weight	205.63 g/mol
Synonyms	(S)-1-(2,5-Difluorophenyl)propan-1-amine hydrochloride; (S)-1-Amino-1-(2,5-difluorophenyl)propane hydrochloride; (S)-2,5-Difluoro-α-ethylbenzylamine hydrochloride; (S)-α-Ethyl-2,5-difluorobenzylamine hydrochloride; (1S)-1-(2,5-Difluorophenyl)propan-1-amine hydrochloride; (S)-1-(2,5-Difluorophenyl)propylamine hydrochloride; (S)-1-(2,5-Difluorophenyl)propan-1-amine HCl
EINECS	Contact for details

Quality Control

Our (S)-1-(2,5-Difluorophenyl)Propan-1-Amine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification, to ensure it meets the high standards required for research and development applications. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request to support your regulatory and quality assurance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.