Description

(D-Trp6)-Lhrh (1-6) Amide CAS NO 1217367-73-1 is a synthetic peptide fragment, specifically a modified analogue of the Luteinizing Hormone-Releasing Hormone (LHRH). This compound is a critical intermediate and research tool in the development of targeted peptide-based therapeutics. It is primarily utilized by pharmaceutical R&D departments, biotechnology companies, and academic research institutions focused on endocrinology, oncology, and reproductive medicine.

Application

• Pharmaceutical Research & Development: Serves as a key intermediate in the synthesis of novel LHRH/GnRH agonist and antagonist analogues for therapeutic applications.
• Endocrinology Studies: Used as a reference standard and active probe in biochemical assays to study the structure-activity relationship (SAR) of gonadotropin-releasing hormone receptors.
• Oncology Research: Investigated for its potential role in developing targeted therapies for hormone-dependent cancers, such as prostate and breast cancer.
• Peptide Chemistry: Employed as a building block in solid-phase peptide synthesis (SPPS) for creating longer, more complex peptide sequences.
• Bioconjugation & Drug Delivery: Acts as a targeting moiety or linker in the design of peptide-drug conjugates (PDCs) due to its receptor-binding properties.
• Diagnostic Development: Potential use in the development of immunoassays or imaging agents for detecting specific hormonal pathways.

Basic Information

Item	Detail
Product Name	(D-Trp6)-Lhrh (1-6) Amide
CAS No.	1217367-73-1
Molecular Formula	C41H55N11O8
Molecular Weight	822.0 g/mol
Synonyms	(D-Tryptophan6)-LHRH (1-6) amide; (D-Trp6)-GnRH (1-6) amide; pGlu-His-Trp-Ser-Tyr-D-Trp-NH2; Gonadorelin (1-6) amide, 6-D-tryptophan-; Luteinizing Hormone-Releasing Hormone (1-6) amide, 6-D-Trp-; D-Trp6-LHRH(1-6)NH2; D-Trp6-GnRH(1-6)NH2
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request, detailing key parameters such as purity (by HPLC), peptide content, and identity confirmation. We adhere to cGMP principles for manufacturing critical intermediates to support our clients' regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. Due to its hygroscopic nature, allow the vial to equilibrate to room temperature in a desiccator before opening to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Peptide Content	≥ 80.0%
Amino Acid Analysis	± 10% of theoretical
Water Content (KF)	≤ 5.0%
Single Impurity (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.