Description

H-Arg(Pbf)-Otbu · HCl is a protected arginine derivative, specifically the tert-butyl ester hydrochloride salt of Nω-2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl (Pbf) arginine. This compound is a critical building block in solid-phase peptide synthesis (SPPS), where it provides orthogonal protection for the guanidino group of arginine, preventing side reactions and enabling the synthesis of complex peptides with high purity. It is an essential raw material for researchers and manufacturers in pharmaceutical development, biotechnology, and academic research focused on peptide-based therapeutics, diagnostics, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key protected amino acid derivative for the controlled incorporation of arginine residues into peptide chains.
• Pharmaceutical R&D: For the research and development of novel peptide drugs, including hormones, antimicrobial peptides, and enzyme inhibitors.
• Bioconjugation & Labeling: Used in the synthesis of peptide tags, probes, and conjugates for diagnostic and imaging applications.
• Combinatorial Chemistry: A valuable component in libraries for high-throughput screening to discover new bioactive compounds.
• Academic Research: Fundamental studies in peptide chemistry, structure-activity relationships (SAR), and protein engineering.
• Custom Peptide Service Providers: A standard reagent for CROs and CDMOs offering bespoke peptide synthesis services.

Basic Information

Product Name	H-Arg(Pbf)-Otbu · HCl
CAS No.	1217317-67-3
Molecular Formula	C24H40ClN4O6S
Molecular Weight	557.11 g/mol
Synonyms	Nω-(2,2,4,6,7-Pentamethyldihydrobenzofuran-5-sulfonyl)-L-arginine tert-butyl ester hydrochloride; Fmoc-Arg(Pbf)-OtBu HCl (common ordering name); L-Arginine, N2-[(9H-fluoren-9-ylmethoxy)carbonyl]-Nω-[2,2,4,6,7-pentamethyldihydro-5-benzofuranylsulfonyl]-, 1,1-dimethylethyl ester, hydrochloride (related); Boc-Arg(Pbf)-OtBu HCl (Boc-protected variant); Pbf-Arg-OtBu · HCl; H-Arg(Pbf)-OtBu hydrochloride; tert-Butyl Nω-(Pbf)-L-argininate hydrochloride
EINECS	Contact for details

Quality Control

Our H-Arg(Pbf)-Otbu · HCl is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and NMR for structural confirmation, to ensure it meets the high standards required for peptide synthesis. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability, consistency, and reliability for your critical research and production processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive). For long-term storage, consider desiccation. Keep container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Assay (Titration)	97.0% - 102.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.