Description

4-Amino-3-Fluoro-5-Nitrobenzotrifluoride is a high-value, multi-functional aromatic intermediate featuring amino, fluoro, nitro, and trifluoromethyl substituents. This compound matters for its role as a critical building block in the synthesis of complex molecules, particularly in advanced pharmaceutical and agrochemical research. Industries that require it include pharmaceutical development for creating active pharmaceutical ingredients (APIs), agrochemical manufacturing for novel crop protection agents, and specialty chemical synthesis for dyes and advanced materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug molecules, particularly those targeting central nervous system (CNS) disorders and oncology.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, leveraging the bioactivity of the fluorine and nitro groups.
• Dye and Pigment Manufacturing: Serves as a building block for high-performance, light-fast dyes and organic pigments.
• Liquid Crystal and OLED Material Research: The trifluoromethyl and aromatic core structure make it valuable for developing advanced electronic display materials.
• Cross-Coupling Reactions: The amino group provides a handle for further functionalization via Buchwald-Hartwig amination or other palladium-catalyzed reactions.
• Fluorinated Building Block: Essential for introducing fluorine atoms into target molecules to enhance metabolic stability, bioavailability, and lipophilicity.

Basic Information

Product Name	4-Amino-3-Fluoro-5-Nitrobenzotrifluoride
CAS No.	1217304-18-1
Molecular Formula	C7H4F4N2O2
Molecular Weight	224.12 g/mol
Synonyms	3-Fluoro-5-nitro-4-(trifluoromethyl)aniline; 4-Amino-3-fluoro-5-nitro-α,α,α-trifluorotoluene; 2-Fluoro-6-nitro-4-(trifluoromethyl)aniline; 1-Amino-2-fluoro-4-nitro-5-(trifluoromethyl)benzene; Benzene, 1-amino-2-fluoro-4-nitro-5-(trifluoromethyl)-; AFNTF; 4-Amino-α,α,α,3-tetrafluoro-5-nitrobenzene
EINECS	Contact for details

Quality Control

Our 4-Amino-3-Fluoro-5-Nitrobenzotrifluoride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via FT-IR and NMR spectroscopy, to ensure compliance with customer specifications and industry standards. Certificates of Analysis (COA) detailing all test results are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be amber-colored or stored in light-resistant packaging.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.