Description

1-(4-Fluorophenyl)Cyclobutan-1-Amine, Hcl is a high-purity, advanced pharmaceutical intermediate characterized by its unique cyclobutane core and fluorinated aromatic system. This compound is of significant commercial interest for its role as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and metabolic disorder research. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and biotechnology industries seeking to develop new therapeutic candidates.

Application

• Pharmaceutical Intermediate: A key synthon for the research and development of new drug candidates, especially in medicinal chemistry programs.
• Active Pharmaceutical Ingredient (API) Synthesis: Serves as a crucial precursor in multi-step synthetic routes for target molecules in preclinical and clinical studies.
• CNS Drug Discovery: Used in the synthesis of compounds targeting neurological receptors and pathways due to its structural motif.
• Chemical Biology & Proteomics: Employed as a scaffold or labeling agent in the design of chemical probes for target identification and validation.
• Process Chemistry & Scale-Up: Supplied for route scouting, optimization, and pilot-scale manufacturing under cGMP conditions.
• Contract Research & Manufacturing (CRO/CMO): Sourced by service organizations supporting global pharmaceutical development pipelines.

Basic Information

Product Name	1-(4-Fluorophenyl)Cyclobutan-1-Amine, Hcl
CAS No.	1216658-90-0
Molecular Formula	C10H13FN • HCl
Molecular Weight	201.68 g/mol (Free base: 165.22 g/mol)
Synonyms	1-(4-Fluorophenyl)cyclobutan-1-amine hydrochloride; 4-Fluoro-α-(cyclobutyl)benzenemethanamine hydrochloride; 1-Amino-1-(4-fluorophenyl)cyclobutane hydrochloride; 1-(4-Fluorophenyl)cyclobutanamine HCl; (4-Fluorophenyl)cyclobutylamine hydrochloride; 1-(p-Fluorophenyl)cyclobutan-1-amine hydrochloride
EINECS	Contact for details

Quality Control

Our 1-(4-Fluorophenyl)Cyclobutan-1-Amine, Hcl is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and stringent controls for residual solvents and impurities. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to ensure traceability and compliance with your research or cGMP requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	< 10 ppm
Residual Solvents (GC)	Complies with ICH Q3C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.