Description

4-(n-Boc-Aminoxyacetamido)Benzyl Ethylenediaminetetraacetic Acid, Tetra(T-Butyl) Ester is a specialized, protected derivative of ethylenediaminetetraacetic acid (EDTA) designed for advanced synthetic applications. This compound is critically important as a high-value building block and chelating agent precursor in the development of novel pharmaceuticals, diagnostic agents, and bioconjugation platforms. It is primarily needed by research institutions and industrial manufacturers in the pharmaceutical, biotechnology, and advanced materials sectors for creating targeted drug delivery systems and complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel chelator-drug conjugates for targeted radiotherapy and chemotherapy.
• Bioconjugation Reagent: Used to attach metal chelating groups to antibodies, proteins, or peptides for diagnostic imaging (e.g., PET, SPECT) and therapeutic applications.
• Radiopharmaceutical Development: Serves as a protected scaffold for creating bifunctional chelators that bind diagnostic or therapeutic radiometals (e.g., 68Ga, 177Lu, 99mTc).
• Research Chemical: Employed in academic and industrial R&D for studying metal ion coordination chemistry and developing new sensing molecules.
• Advanced Material Synthesis: A building block for creating functionalized polymers or surfaces with specific metal-binding capabilities.
• Protecting Group Strategy: The tert-butyl ester and Boc-protected aminoxy groups allow for selective deprotection and further functionalization in multi-step organic syntheses.

Basic Information

Product Name	4-(n-Boc-Aminoxyacetamido)Benzyl Ethylenediaminetetraacetic Acid, Tetra(T-Butyl) Ester
CAS No.	1216552-27-0
Molecular Formula	C42H68N4O13
Molecular Weight	837.01 g/mol
Synonyms	EDTA-tetra(t-butyl) ester-Boc-Aminooxyacetyl-benzyl derivative; 4-[[(1,1-Dimethylethoxy)carbonyl]amino]oxyacetamidobenzyl-EDTA tetra-tert-butyl ester; Boc-Aoa-Bn-EDTA-tBu4; Tetra-tert-butyl 2,2',2'',2'''-(2-(4-((2-((tert-butoxycarbonyl)amino)oxy)acetamido)benzyl)-1,2-ethanediylbis(nitrilo))tetraacetate; Bifunctional Chelator Precursor; Protected EDTA Derivative; tBu4-EDTA-Aoa-Boc-Benzyl
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to stringent quality protocols to ensure batch-to-batch consistency and high chemical purity for sensitive research and development applications. Certificates of Analysis (COA) are provided with each shipment, detailing key parameters such as purity, identity, and impurity profiles. While not a bulk active pharmaceutical ingredient (API), our quality systems are designed to support cGMP-compliant workflows for our customers in the radiopharmaceutical and bioconjugation sectors.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions or a dry inert atmosphere to maintain stability. Allow the sealed container to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.