Description

α-Me-Phe(4-I)-Oh CAS NO 1215092-16-2 is a high-purity, non-natural amino acid derivative featuring a methyl group at the alpha position and an iodine substituent on the phenyl ring. This specific structural modification makes it a valuable and versatile chiral building block for advanced organic synthesis and pharmaceutical research. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel peptide-based therapeutics, enzyme inhibitors, and other bioactive compounds.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel peptide drugs and enzyme inhibitors.
• Peptidomimetics: Used to introduce steric hindrance and modulate the pharmacokinetic properties of peptide analogs.
• Medicinal Chemistry: Serves as a building block for structure-activity relationship (SAR) studies in drug discovery programs.
• Bioconjugation: The iodine substituent offers a handle for further functionalization via cross-coupling reactions (e.g., Suzuki, Sonogashira).
• Chemical Biology Probes: Incorporation into peptides to create probes for studying protein-protein interactions and enzyme mechanisms.
• Academic Research: Employed in synthetic organic chemistry for methodological development and the synthesis of complex natural product analogs.

Basic Information

Product Name	α-Me-Phe(4-I)-Oh
CAS No.	1215092-16-2
Molecular Formula	C10H12INO2
Molecular Weight	305.11 g/mol
Synonyms	(2S)-2-Amino-3-(4-iodophenyl)-2-methylpropanoic acid; (S)-2-Amino-3-(4-iodophenyl)-2-methylpropanoic acid; L-α-Methyl-4-iodophenylalanine; (S)-α-Methyl-4-iodo-DL-phenylalanine; 4-Iodo-α-methyl-L-phenylalanine; NSC 760463; α-Me-Phe(4-I)-OH; 2-Methyl-2-amino-3-(4-iodophenyl)propionic acid
EINECS	Contact for details

Quality Control

Every batch of α-Me-Phe(4-I)-Oh is manufactured under strict quality management systems. We provide comprehensive analytical data to ensure the product meets the high standards required for research and development. Our quality control includes rigorous testing for identity, purity, and chiral integrity. Certificates of Analysis (COA) detailing specifications such as HPLC purity, chiral purity, and residual solvent content are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.