Description

3-(Difluoromethoxy)-5-Fluorobenzaldehyde is a high-purity fluorinated aromatic aldehyde building block of significant interest in advanced organic synthesis. This compound matters for its role as a key intermediate in the development of novel active pharmaceutical ingredients (APIs) and agrochemicals, where its unique difluoromethoxy and fluorine substituents can modulate biological activity and metabolic stability. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to incorporate sophisticated fluorinated motifs into their target molecules.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of novel drug candidates, particularly in central nervous system (CNS) and oncology research.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides with enhanced efficacy and environmental profile.
• Liquid Crystal Materials: Serves as a precursor for fluorinated liquid crystal compounds used in advanced display technologies.
• Organic Electronic Materials: Employed in the synthesis of fluorinated organic semiconductors and charge-transport materials.
• Cross-Coupling Reactions: The aldehyde group allows for further functionalization via reactions like reductive amination or condensation, while the aromatic ring is amenable to metal-catalyzed cross-couplings.
• Custom Synthesis & Contract Manufacturing: A valuable starting material for custom synthesis houses serving the life sciences sector.

Basic Information

Product Name	3-(Difluoromethoxy)-5-Fluorobenzaldehyde
CAS No.	1214386-38-5
Molecular Formula	C8H5F3O2
Molecular Weight	190.12 g/mol
Synonyms	5-Fluoro-3-(difluoromethoxy)benzaldehyde; 3-Difluoromethoxy-5-fluorobenzaldehyde; Benzaldehyde, 3-(difluoromethoxy)-5-fluoro-; 1214386-38-5; 5-Fluoro-α,α-difluoroanisole-3-carboxaldehyde
EINECS	Contact for details

Quality Control

Every batch of 3-(Difluoromethoxy)-5-Fluorobenzaldehyde is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for research and scale-up applications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available for each lot upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (15-25°C). This material is easily oxidized and should be handled and stored under an inert atmosphere (e.g., nitrogen or argon) for long-term stability. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.