Description

4-(Difluoromethoxy)-2-Fluorobenzaldehyde is a high-purity fluorinated aromatic aldehyde building block of significant importance in advanced organic synthesis. Its unique difluoromethoxy and fluorine substituents make it a critical intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is primarily sought after by R&D and production teams in the pharmaceutical and agrochemical industries for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, metabolic diseases, and oncology.
• Agrochemical Synthesis: Used in the research and production of next-generation herbicides, fungicides, and insecticides, where the difluoromethoxy group can enhance bioavailability and metabolic stability.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated components in electronic display materials, contributing to improved dielectric anisotropy and thermal stability.
• Functional Material Development: Employed in creating advanced polymers, ligands for catalysis, and specialty dyes where fluorine incorporation is desired for performance enhancement.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for bespoke synthesis projects requiring high-value fluorinated intermediates.

Basic Information

Product Name	4-(Difluoromethoxy)-2-Fluorobenzaldehyde
CAS No.	1214358-05-0
Molecular Formula	C8H5F3O2
Molecular Weight	190.12 g/mol
Synonyms	2-Fluoro-4-(difluoromethoxy)benzaldehyde; 4-(Difluoromethoxy)-2-fluorobenzenecarboxaldehyde; Benzaldehyde, 4-(difluoromethoxy)-2-fluoro-; 2-Fluoro-4-difluoromethoxybenzaldehyde
EINECS	Contact for details

Quality Control

Our 4-(Difluoromethoxy)-2-Fluorobenzaldehyde is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide full traceability and detailed Certificates of Analysis (COA) with every shipment, confirming compliance with customer specifications and industry best practices.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong bases, reducing agents, and heat sources. For long-term storage, consider an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.