Description

2-Difluoromethoxy-6-Fluorobenzaldehyde is a high-purity fluorinated aromatic aldehyde building block of significant interest in advanced organic synthesis. This compound matters for its role as a key intermediate in the development of novel active pharmaceutical ingredients (APIs) and agrochemicals, where the difluoromethoxy and fluorine substituents impart unique electronic and metabolic properties. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to introduce specific fluorinated motifs into their target molecules.

Application

• Pharmaceutical Intermediate: A crucial building block for synthesizing novel drug candidates, particularly in medicinal chemistry programs targeting CNS disorders, anti-infectives, and oncology.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where fluorination enhances biological activity and environmental stability.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized fluorinated ligands used in asymmetric catalysis and material science.
• Functional Material Research: Employed in the synthesis of fluorinated liquid crystals, polymers, and electronic materials requiring specific dielectric properties.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for scale-up and production under cGMP guidelines.
• Academic and Industrial R&D: A valuable reagent for methodological development in organic chemistry, exploring new fluorination and functionalization reactions.

Basic Information

Product Name	2-Difluoromethoxy-6-Fluorobenzaldehyde
CAS No.	1214333-68-2
Molecular Formula	C8H5F3O2
Molecular Weight	190.12 g/mol
Synonyms	6-Fluoro-2-(difluoromethoxy)benzaldehyde; 2-Fluoro-6-(difluoromethoxy)benzaldehyde; Benzaldehyde, 2-(difluoromethoxy)-6-fluoro-; 2-(Difluoromethoxy)-6-fluorobenzaldehyde; 6-Fluoro-2-difluoromethoxybenzaldehyde; 2-Difluoromethoxy-6-fluorobenzenecarboxaldehyde
EINECS	Contact for details

Quality Control

Our 2-Difluoromethoxy-6-Fluorobenzaldehyde is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and MS, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment supports applications requiring reproducible results and regulatory compliance in research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed and under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5% w/w
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.