Description

2-(Difluoromethoxy)-5-Fluoroaniline is a specialized fluorinated aniline derivative, serving as a critical building block in advanced organic synthesis. Its unique difluoromethoxy and fluoro substituents make it a valuable intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is primarily sought by pharmaceutical and agrochemical R&D sectors for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, oncology, and anti-infective therapies.
• Agrochemical Synthesis: Used in the research and production of modern pesticides and herbicides, where the fluorine atoms enhance biological activity, metabolic stability, and environmental profile.
• Liquid Crystal Materials: Serves as a building block for fluorinated components in liquid crystal displays (LCDs), improving dielectric anisotropy and thermal stability.
• Functional Polymer Monomer: Incorporated into specialty polymers to impart unique properties such as chemical resistance, low surface energy, and enhanced durability.
• Organic Electronic Materials: Utilized in the development of materials for organic light-emitting diodes (OLEDs) and organic photovoltaics (OPVs).
• Chemical Research & Development: A versatile reagent for academic and industrial research in medicinal chemistry and material science.

Basic Information

Product Name	2-(Difluoromethoxy)-5-Fluoroaniline
CAS No.	1214329-65-3
Molecular Formula	C7H6F3NO
Molecular Weight	177.12 g/mol
Synonyms	5-Fluoro-2-(difluoromethoxy)aniline; 2-Amino-4-fluorophenyl difluoromethyl ether; 5-Fluoro-2-(difluoromethoxy)benzenamine; 2-(Difluoromethoxy)-5-fluoro-benzenamine; 1214329-65-3; DFMFA
EINECS	Contact for details

Quality Control

Our production of 2-(Difluoromethoxy)-5-Fluoroaniline adheres to stringent quality management protocols. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and MS, to ensure high purity and consistency. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with each shipment. We support compliance with cGMP, ISO, and REACH standards for global supply.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong oxidizing agents, strong acids, and strong bases. The compound may be moisture-sensitive; handle and store under an inert atmosphere for long-term stability.

Specification

Item	Specification
Appearance	Light yellow to brown crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.