Description

3-(2-Chloropyrimidin-4-Yl)-7-Nitro-1H-Indole is a high-purity heterocyclic building block of significant interest in advanced organic synthesis. This compound is valued for its dual functionalization, featuring both a reactive chloropyrimidine group and a nitro-substituted indole core, enabling its use in complex molecular construction. It is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of kinase inhibitors and other small-molecule drug candidates targeting various therapeutic areas.
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and plant growth regulators.
• Chemical Biology Probe Synthesis: Serves as a scaffold for creating molecular probes to study biological pathways and protein functions.
• Material Science: A potential building block for organic electronic materials and advanced polymers due to its conjugated structure.
• Cross-Coupling Reactions: The chloropyrimidine moiety is amenable to palladium-catalyzed cross-coupling (e.g., Suzuki, Buchwald-Hartwig) for library synthesis.
• Nucleophilic Aromatic Substitution: The chlorine atom can be readily displaced by various nucleophiles to introduce diverse functionality.

Basic Information

Product Name	3-(2-Chloropyrimidin-4-Yl)-7-Nitro-1H-Indole
CAS No.	1214264-48-8
Molecular Formula	C₁₂H₇ClN₄O₂
Molecular Weight	274.66 g/mol
Synonyms	7-Nitro-3-(2-chloropyrimidin-4-yl)-1H-indole; 1H-Indole, 3-(2-chloro-4-pyrimidinyl)-7-nitro-; 3-(2-Chloro-4-pyrimidinyl)-7-nitro-1H-indole; 3-(2-Chloro-pyrimidin-4-yl)-7-nitro-1H-indole; 3-(2-Chloropyrimidin-4-yl)-7-nitroindole; 7-Nitro-3-(2-chloro-4-pyrimidinyl)indole
EINECS	Contact for details

Quality Control

Our 3-(2-Chloropyrimidin-4-Yl)-7-Nitro-1H-Indole is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity for research and development applications. Each lot is characterized by advanced analytical techniques including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	Yellow to orange solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.