Description

(1S)Cyclopropyl[4-(Trifluoromethyl)Phenyl]Methylamine is a chiral amine building block of significant interest in advanced organic synthesis. Its core value lies in the combination of a cyclopropyl group and a trifluoromethylphenyl moiety, which are both highly sought-after motifs for modulating the physicochemical and pharmacological properties of target molecules. This compound is essential for research chemists and process development scientists in the pharmaceutical and agrochemical industries who require high-purity, structurally complex intermediates for drug discovery and development programs.

Application

• Pharmaceutical Intermediate: A key chiral precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and antiviral targets.
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances biological activity and metabolic stability.
• Ligand & Catalyst Development: Serves as a backbone for creating chiral ligands and organocatalysts used in asymmetric synthesis.
• Material Science Precursor: Potential building block for advanced organic materials, such as liquid crystals or polymers, where its rigid structure and fluorine content can impart unique properties.
• Medicinal Chemistry SAR Studies: Employed in structure-activity relationship (SAR) explorations to investigate the impact of the cyclopropyl and trifluoromethyl groups on potency and selectivity.
• Process Chemistry & Scale-up: Supplied for route scouting, optimization, and cGMP manufacturing of clinical trial materials.

Basic Information

Item	Detail
Product Name	(1S)Cyclopropyl[4-(Trifluoromethyl)Phenyl]Methylamine
CAS No.	1213959-29-5
Molecular Formula	C11H12F3N
Molecular Weight	215.21 g/mol
Synonyms	(1S)-1-Cyclopropyl-1-[4-(trifluoromethyl)phenyl]methanamine; (S)-1-(4-(Trifluoromethyl)phenyl)cyclopropanemethylamine; (S)-α-Cyclopropyl-4-(trifluoromethyl)benzylamine; (S)-[4-(Trifluoromethyl)phenyl](cyclopropyl)methylamine; (S)-1-Cyclopropyl-1-(4-trifluoromethylphenyl)methylamine; (S)-CPTMA; (1S)-CPTMA; (S)-Trifluoromethyl Phenyl Cyclopropyl Methyl Amine
EINECS	Contact for details

Quality Control

Every batch of (1S)Cyclopropyl[4-(Trifluoromethyl)Phenyl]Methylamine is produced and tested under a strict quality management system. We ensure compliance with relevant industry standards for advanced pharmaceutical intermediates. Comprehensive analytical testing, including chiral purity verification by HPLC, is performed to guarantee consistent identity, purity, and enantiomeric excess. A detailed Certificate of Analysis (COA) is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.