Description

(tert-Butoxy)Carbonyl L-Phe(2-Me, 4-F)-Oh is a protected, non-natural amino acid derivative featuring a tert-butoxycarbonyl (Boc) protecting group and a modified phenylalanine side chain with methyl and fluorine substituents. This compound is a critical high-purity building block for the synthesis of complex peptides and peptidomimetics, offering precise control over molecular structure and properties. It is primarily utilized by pharmaceutical R&D and fine chemical synthesis teams developing novel therapeutic agents, including protease inhibitors and receptor modulators.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel peptide-based drugs and bioactive molecules.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis (SPPS) to introduce a modified phenylalanine residue with enhanced stability or altered binding characteristics.
• Protease Inhibitor Development: Serves as a core component in the design of inhibitors targeting specific enzymes, leveraging the fluorine and methyl groups for optimized interaction.
• Chemical Biology Research: Employed in the study of protein-protein interactions and the creation of labeled or tagged peptides for diagnostic and research purposes.
• Library Synthesis: A valuable building block for generating diverse combinatorial libraries for high-throughput screening in drug discovery campaigns.
• Advanced Material Science: Potential use in the synthesis of specialized polymers or dendrimers with unique surface properties.

Basic Information

Product Name	(tert-Butoxy)Carbonyl L-Phe(2-Me, 4-F)-Oh
CAS No.	1213938-19-2
Molecular Formula	C15H20FNO4
Molecular Weight	297.32 g/mol
Synonyms	Boc-L-2-Methyl-4-fluorophenylalanine; Boc-2-Me-4-F-Phe-OH; N-(tert-Butoxycarbonyl)-2-methyl-4-fluoro-L-phenylalanine; (2S)-3-[2-Methyl-4-fluorophenyl]-2-[(2-methylpropan-2-yl)oxycarbonylamino]propanoic acid; N-Boc-2-methyl-4-fluoro-L-phenylalanine; Fmoc-L-Phe(2-Me-4-F)-OH precursor; Boc-Phe(2Me,4F)-OH; Protected 4-fluoro-2-methylphenylalanine derivative
EINECS	Contact for details

Quality Control

Our (tert-Butoxy)Carbonyl L-Phe(2-Me, 4-F)-Oh is manufactured under strict quality systems to ensure batch-to-batch consistency and high chemical purity, essential for sensitive pharmaceutical applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity (typically ≥97% by HPLC), chiral purity, and impurity profiles. We support compliance with cGMP and ICH guidelines for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.