Description

(1R)-1-(4-Chloro-3-Methylphenyl)-2,2,2-Trifluoroethylamine is a high-purity chiral amine building block of significant interest in advanced organic synthesis. This compound matters for its role as a critical intermediate in the development of active pharmaceutical ingredients (APIs) and agrochemicals, where its specific stereochemistry and trifluoromethyl group are key to biological activity. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to introduce a chiral, fluorinated motif into their target molecules.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of novel therapeutic agents, particularly in central nervous system (CNS) and metabolic disease targets.
• Agrochemical Synthesis: Used in the production of advanced pesticides and herbicides, where the trifluoromethyl group enhances lipophilicity and metabolic stability.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis.
• Fluorinated Compound Research: An essential building block in medicinal and materials chemistry for introducing the CF3 group, which can dramatically alter physical and biological properties.
• Process Chemistry & Scale-up: Employed in route scouting and optimization for the commercial manufacturing of complex molecules.

Basic Information

Product Name	(1R)-1-(4-Chloro-3-Methylphenyl)-2,2,2-Trifluoroethylamine
CAS No.	1213918-45-6
Molecular Formula	C9H9ClF3N
Molecular Weight	223.62 g/mol
Synonyms	(1R)-1-(4-Chloro-3-methylphenyl)-2,2,2-trifluoroethanamine; (R)-1-(4-Chloro-3-methylphenyl)-2,2,2-trifluoroethylamine; (1R)-1-(4-Chloro-3-Methylphenyl)-2,2,2-Trifluoroethanamine; (R)-α-(4-Chloro-3-methylphenyl)-2,2,2-trifluoroethylamine; (1R)-1-(4-Chloro-3-Methylphenyl)-2,2,2-Trifluoroethylamine; CAS 1213918-45-6; Benzenemethanamine, 4-chloro-α-(trifluoromethyl)-3-methyl-, (αR)-
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. We provide comprehensive analytical data including chiral purity, chemical purity, and impurity profiles. Certificates of Analysis (COA) are available upon request, detailing specifications such as assay, enantiomeric excess, and residual solvents as relevant for pharmaceutical-grade intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (typically 15-25°C). This material is light-sensitive and should be handled and stored accordingly to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Loss on Drying	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.