Description

(1R)-1-[3-Nitro-5-(Trifluoromethyl)Phenyl]Ethylamine is a high-purity chiral amine building block of significant importance in advanced organic synthesis. Its value lies in its unique molecular architecture, featuring both a nitro group and a trifluoromethyl group on an aromatic ring attached to a chiral ethylamine side chain, enabling precise stereochemical control in target molecule construction. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries developing novel active ingredients, particularly where the introduction of fluorine atoms is critical for modulating biological activity, metabolic stability, and lipophilicity.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new active pharmaceutical ingredients (APIs), especially in central nervous system (CNS) and oncology drug candidates.
• Agrochemical Synthesis: Used in the creation of advanced herbicides, fungicides, and insecticides where the trifluoromethyl group enhances product efficacy and environmental stability.
• Ligand and Catalyst Development: Serves as a precursor for synthesizing chiral ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Employed in the development of specialty polymers and advanced organic materials with specific electronic or optical properties.
• Chemical Biology Probes: Utilized as a building block for creating molecular probes to study enzyme mechanisms and biological pathways.

Basic Information

Product Name	(1R)-1-[3-Nitro-5-(Trifluoromethyl)Phenyl]Ethylamine
CAS No.	1213678-78-4
Molecular Formula	C9H9F3N2O2
Molecular Weight	234.18 g/mol
Synonyms	(R)-1-(3-Nitro-5-(trifluoromethyl)phenyl)ethan-1-amine; (1R)-1-[3-Nitro-5-(trifluoromethyl)phenyl]ethanamine; (R)-α-Methyl-3-nitro-5-(trifluoromethyl)benzylamine; (R)-1-(3-Nitro-5-trifluoromethylphenyl)ethylamine; (R)-1-(3-Nitro-5-(trifluoromethyl)phenyl)ethylamine; (R)-3-Nitro-5-(trifluoromethyl)benzylamine, α-methyl-; (R)-1-(3-Nitro-5-(trifluoromethyl)phenyl)ethan-1-amine hydrochloride (salt form)
EINECS	Contact for details

Quality Control

Our production of (1R)-1-[3-Nitro-5-(Trifluoromethyl)Phenyl]Ethylamine adheres to stringent quality protocols to ensure batch-to-batch consistency and high chiral purity, which is critical for its application in regulated synthesis. Each lot is characterized using advanced analytical techniques including chiral HPLC, NMR, and MS. A comprehensive Certificate of Analysis (COA) detailing identity, purity, enantiomeric excess, and impurity profile is provided with every shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound may be hygroscopic; keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.