Description

(1S)-6-Fluoro-1,2,3,4-Tetrahydronaphthalen-1-Amine is a chiral, fluorinated tetralin derivative serving as a high-value pharmaceutical intermediate and building block in organic synthesis. Its core value lies in its precise stereochemistry and fluorine atom, which are critical for modulating the biological activity, metabolic stability, and lipophilicity of target drug candidates. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly those working on central nervous system (CNS) agents, receptor modulators, and other bioactive molecules.

Application

• Pharmaceutical Intermediate: A key chiral building block for the synthesis of novel active pharmaceutical ingredients (APIs), especially in neurological and psychiatric drug discovery.
• Agrochemical Research: Used in the development of advanced pesticides and herbicides, where the fluorine atom enhances compound stability and efficacy.
• Chemical Biology Probe: Serves as a scaffold for creating molecular probes to study enzyme function and receptor-ligand interactions.
• Asymmetric Synthesis: Employed as a starting material or intermediate in catalytic asymmetric reactions to construct complex, enantiomerically pure molecules.
• Material Science Precursor: Potential use in the synthesis of specialty chemicals and advanced materials requiring fluorinated aromatic components.

Basic Information

Item	Details
Product Name	(1S)-6-Fluoro-1,2,3,4-Tetrahydronaphthalen-1-Amine
CAS No.	1213465-25-8
Molecular Formula	C10H12FN
Molecular Weight	165.21 g/mol
Synonyms	(1S)-6-Fluoro-1,2,3,4-tetrahydro-1-naphthalenamine; (S)-6-Fluoro-1,2,3,4-tetrahydronaphthalen-1-amine; (1S)-6-Fluoro-1-amino-1,2,3,4-tetrahydronaphthalene; 6-Fluoro-(1S)-1,2,3,4-tetrahydro-1-naphthylamine; (S)-1-Amino-6-fluoro-1,2,3,4-tetrahydronaphthalene; 6-Fluoro-(S)-tetralin-1-amine; (1S)-1-Amino-6-fluoro-1,2,3,4-tetrahydronaphthalene
EINECS	Contact for details

Quality Control

Our (1S)-6-Fluoro-1,2,3,4-Tetrahydronaphthalen-1-Amine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity analysis by HPLC, to ensure compliance with exacting standards for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing identity, purity, enantiomeric excess, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.