Description

(1S)-1-(3,4-Dimethylphenyl)-2,2,2-Trifluoroethylamine is a high-purity chiral amine building block of significant importance in advanced organic synthesis. Its value lies in its trifluoromethyl and aromatic substituents, which are critical for modulating the physicochemical and metabolic properties of target molecules. This compound is primarily needed by pharmaceutical and agrochemical R&D organizations for the development of novel active ingredients, particularly where the introduction of fluorine atoms is desired for enhanced bioactivity and stability.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new active pharmaceutical ingredients (APIs), especially for central nervous system (CNS) and metabolic disease targets.
• Agrochemical Synthesis: Used in the creation of advanced herbicides, fungicides, and insecticides where the trifluoromethyl group improves efficacy and environmental profile.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Employed in the synthesis of specialty polymers and advanced organic materials with unique electronic properties.
• Fluorine Chemistry Studies: A valuable compound for academic and industrial research focused on incorporating fluorine into complex molecular architectures.

Basic Information

Product Name	(1S)-1-(3,4-Dimethylphenyl)-2,2,2-Trifluoroethylamine
CAS No.	1213453-44-1
Molecular Formula	C10H12F3N
Molecular Weight	203.20 g/mol
Synonyms	(1S)-1-(3,4-Dimethylphenyl)-2,2,2-trifluoroethanamine; (S)-1-(3,4-Dimethylphenyl)-2,2,2-trifluoroethylamine; (S)-α-(3,4-Dimethylphenyl)-2,2,2-trifluoroethylamine; (S)-3,4-Dimethyl-α-(trifluoromethyl)benzylamine; (1S)-1-(3,4-Dimethylphenyl)-2,2,2-trifluoro-1-ethanamine; (S)-1-(3,4-Xylyl)-2,2,2-trifluoroethylamine
EINECS	Contact for details

Quality Control

Our (1S)-1-(3,4-Dimethylphenyl)-2,2,2-Trifluoroethylamine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure compliance with exacting R&D and process chemistry standards. A comprehensive Certificate of Analysis (COA) detailing identity, purity (typically ≥98%), enantiomeric excess, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.