Description

(1R)-2,2,2-Trifluoro-1-Naphthylethylamine is a high-purity chiral amine building block featuring a naphthyl group and a trifluoroethylamine moiety. This compound is valued for its role as a key intermediate in the synthesis of advanced pharmaceuticals and agrochemicals, where its specific stereochemistry and fluorine atoms are critical for biological activity and metabolic stability. It is primarily needed by research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries for developing new active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A crucial chiral building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and oncology drug candidates.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides, where the fluorine atoms enhance lipophilicity and stability.
• Catalyst and Ligand Preparation: Serves as a precursor for chiral catalysts and ligands used in asymmetric synthesis, enabling the production of enantiomerically pure compounds.
• Material Science Research: Employed in the development of advanced organic materials, such as liquid crystals and organic semiconductors, due to its rigid naphthalene structure.
• Fluorine Chemistry Studies: Acts as a model compound in academic and industrial research focused on introducing trifluoromethyl groups into complex molecular architectures.

Basic Information

Product Name	(1R)-2,2,2-Trifluoro-1-Naphthylethylamine
CAS No.	1213437-22-9
Molecular Formula	C₁₂H₁₀F₃N
Molecular Weight	225.21 g/mol
Synonyms	(R)-1-(1-Naphthyl)-2,2,2-trifluoroethylamine; (R)-α-(Trifluoromethyl)-1-naphthalenemethylamine; (1R)-1-(Naphthalen-1-yl)-2,2,2-trifluoroethan-1-amine; (R)-1-(1-Naphthyl)-2,2,2-trifluoroethanamine; (R)-TFNEA; (R)-TNA; (R)-1-Naphthyltrifluoroethylamine
EINECS	Contact for details

Quality Control

Our (1R)-2,2,2-Trifluoro-1-Naphthylethylamine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity analysis, to ensure it meets the high standards required for pharmaceutical and advanced synthetic applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, enantiomeric excess, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.