Description

(1R)-2,2,2-Trifluoro-1-(2-Methoxyphenyl)Ethylamine is a chiral amine building block of significant interest in advanced organic synthesis. Its value lies in the combination of a trifluoroethyl group and a methoxyphenyl moiety, which are key structural motifs for modulating the physicochemical and biological properties of target molecules. This compound is primarily needed by research and development chemists in the pharmaceutical and agrochemical industries for the creation of novel active ingredients, particularly where fluorine substitution is desired to enhance metabolic stability, lipophilicity, or binding affinity.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new active pharmaceutical ingredients (APIs), especially in CNS and oncology drug discovery.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides where the trifluoromethyl group imparts improved activity and environmental stability.
• Ligand and Catalyst Preparation: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Employed in the synthesis of specialty monomers and polymers with unique electronic or surface properties.
• Fluorine Chemistry Studies: A valuable compound for academic and industrial research focused on the introduction and behavior of fluorine in organic molecules.

Basic Information

Product Name	(1R)-2,2,2-Trifluoro-1-(2-Methoxyphenyl)Ethylamine
CAS No.	1213424-25-9
Molecular Formula	C9H10F3NO
Molecular Weight	205.18 g/mol
Synonyms	(R)-2,2,2-Trifluoro-1-(2-methoxyphenyl)ethanamine; (1R)-1-(2-Methoxyphenyl)-2,2,2-trifluoroethylamine; (R)-α-(Trifluoromethyl)-2-methoxybenzylamine; (R)-1-(2-Methoxyphenyl)-2,2,2-trifluoroethanamine; (R)-TFMPEA; (R)-2-Methoxy-α-(trifluoromethyl)benzylamine
EINECS	Contact for details

Quality Control

Our (1R)-2,2,2-Trifluoro-1-(2-Methoxyphenyl)Ethylamine is produced under strict quality management protocols to ensure batch-to-batch consistency and high purity for research and scale-up applications. We provide comprehensive analytical data, including chiral purity (enantiomeric excess) and chemical purity, verified by techniques such as HPLC, GC, and NMR. Certificates of Analysis (COA) are available for every batch upon request, detailing all relevant specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic (moisture-sensitive) nature, the container should be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Recommended long-term storage temperature is 2-8°C.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% e.e.
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.