Description

n-Boc-3,5-Difluoro-L-Tyrosine is a protected, fluorinated derivative of the essential amino acid L-tyrosine, serving as a critical building block in advanced organic synthesis. This compound is valued for its role in introducing fluorine atoms and the tyrosine phenolic side chain into peptide and small molecule structures under controlled conditions. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of novel therapeutics, including peptide-based drugs and enzyme inhibitors. The Boc-protected amine and the difluorinated aromatic ring make it a versatile intermediate for creating compounds with enhanced metabolic stability and binding affinity.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of novel peptide-based pharmaceuticals and enzyme inhibitors.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis (SPPS) to incorporate a fluorinated tyrosine residue.
• Proteomics Research: Serves as a building block for creating labeled or modified peptides for biochemical and proteomic studies.
• Chemical Biology: Employed in the synthesis of activity-based probes and other tools to study enzyme function and protein-protein interactions.
• Agrochemical Development: Potential intermediate in the synthesis of advanced crop protection agents that require fluorinated amino acid motifs.
• Material Science: Can be utilized in the creation of specialized polymers or coatings with unique properties derived from fluorinated aromatic groups.

Basic Information

Product Name	n-Boc-3,5-Difluoro-L-Tyrosine
CAS No.	1213406-89-3
Molecular Formula	C₁₄H₁₇F₂NO₅
Molecular Weight	317.29 g/mol
Synonyms	(2S)-2-[(tert-Butoxycarbonyl)amino]-3-(3,5-difluoro-4-hydroxyphenyl)propanoic acid; Boc-3,5-Difluoro-L-Tyrosine; Boc-3,5-F₂-Tyr-OH; tert-Butyl (S)-(3,5-difluoro-4-hydroxybenzyl)carbamate; N-(tert-Butoxycarbonyl)-3,5-difluoro-L-tyrosine; 3,5-Difluoro-L-tyrosine, N-Boc-; BOC-Tyr(3,5-F2)-OH; N-Boc-O-3,5-difluoro-L-tyrosine
EINECS	Contact for details

Quality Control

Our n-Boc-3,5-Difluoro-L-Tyrosine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral integrity, to ensure compliance with research and development standards. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request to support your regulatory and quality assurance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent decomposition. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Optical Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.