Description

(1S)-1-[4-(tert-Butyl)Phenyl]-2,2,2-Trifluoroethylamine is a high-purity chiral amine building block of significant interest in advanced organic synthesis. Its value lies in its unique structural features, combining a bulky tert-butylphenyl group with a trifluoroethylamine moiety, which are crucial for modulating the physicochemical and biological properties of target molecules. This compound is primarily needed by research and development chemists in the pharmaceutical and agrochemical industries for the creation of novel active ingredients, particularly where stereochemistry and fluorine incorporation are critical design parameters.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new active pharmaceutical ingredients (APIs), especially in areas targeting central nervous system (CNS) disorders, inflammation, and metabolic diseases.
• Agrochemical Synthesis: Used in the design and synthesis of advanced herbicides, fungicides, and insecticides, where the fluorine atoms and chiral center can enhance activity, selectivity, and environmental stability.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis to create enantiomerically pure compounds.
• Material Science Research: Employed in the synthesis of specialty monomers and polymers where the introduction of fluorine and aromatic groups can alter material properties like solubility, thermal stability, and surface energy.
• Chemical Biology Probe Synthesis: Utilized as a building block for creating molecular probes to study biological pathways and protein-ligand interactions.

Basic Information

Item	Details
Product Name	(1S)-1-[4-(tert-Butyl)Phenyl]-2,2,2-Trifluoroethylamine
CAS No.	1213378-66-5
Molecular Formula	C₁₂H₁₆F₃N
Molecular Weight	231.26 g/mol
Synonyms	(S)-1-[4-(tert-Butyl)phenyl]-2,2,2-trifluoroethanamine; (S)-α-(4-tert-Butylphenyl)-2,2,2-trifluoroethylamine; (1S)-1-(4-tert-Butylphenyl)-2,2,2-trifluoroethanamine; (S)-1-(4-(tert-Butyl)phenyl)-2,2,2-trifluoroethan-1-amine; (S)-4-tert-Butyl-α-(trifluoromethyl)benzylamine; (S)-Tert-Butylphenyl Trifluoroethylamine; (S)-BP-TFEA; (S)-Enantiomer of 1-(4-tert-Butylphenyl)-2,2,2-trifluoroethylamine
EINECS	Contact for details

Quality Control

Our (1S)-1-[4-(tert-Butyl)Phenyl]-2,2,2-Trifluoroethylamine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity determination by HPLC, to ensure compliance with exacting R&D and process chemistry standards. Certificates of Analysis (COA) detailing identity, purity, and enantiomeric excess are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.