Description

(S)-Methyl 9,10-Difluoro-3-Methyl-7-Oxo-3,7-Dihydro-2H-[1,4]Oxazino [2,3,4-Ij]Quinoline-6-Carboxylate is a high-purity, advanced pharmaceutical intermediate with a complex heterocyclic structure. This compound is critical for the synthesis of novel, potent antibacterial agents, particularly within the fluoroquinolone class. It is primarily required by research institutions and pharmaceutical manufacturers engaged in the development of next-generation antibiotics and active pharmaceutical ingredients (APIs).

Application

• Key Intermediate for Antibiotic Synthesis: Serves as a crucial building block in the multi-step synthesis of novel fluoroquinolone antibiotics.
• Pharmaceutical R&D: Used in medicinal chemistry research for structure-activity relationship (SAR) studies and the development of new antibacterial candidates.
• Active Pharmaceutical Ingredient (API) Manufacturing: Employed in the scaled-up production of specific, complex API molecules targeting resistant bacterial strains.
• Process Chemistry & Optimization: Utilized by chemical development teams to establish and refine robust, scalable synthetic routes for target molecules.
• Reference Standard: Can be supplied as a high-purity standard for analytical method development, validation, and quality control in pharmaceutical labs.

Basic Information

Product Name	(S)-Methyl 9,10-Difluoro-3-Methyl-7-Oxo-3,7-Dihydro-2H-[1,4]Oxazino [2,3,4-Ij]Quinoline-6-Carboxylate
CAS No.	1213269-49-8
Molecular Formula	C15H12F2N2O4
Molecular Weight	322.27 g/mol
Synonyms	(S)-9,10-Difluoro-3-methyl-7-oxo-3,7-dihydro-2H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid methyl ester; (S)-Methyl 9,10-difluoro-3-methyl-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylate; (S)-9,10-Difluoro-3-methyl-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid methyl ester; Levofoxacin Intermediate; Advanced Levofloxacin Intermediate; (S)-Configuration Fluoroquinolone Intermediate; CAS 1213269-49-8
EINECS	Contact for details

Quality Control

Our (S)-Methyl 9,10-Difluoro-3-Methyl-7-Oxo-3,7-Dihydro-2H-[1,4]Oxazino [2,3,4-Ij]Quinoline-6-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure it meets the exacting standards required for pharmaceutical development. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The container should be kept in a well-ventilated area and protected from moisture. For long-term storage, consider inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.5%
Chiral Purity (HPLC)	≥ 99.0% (S-Isomer)
Related Substances (HPLC)	Total impurities ≤ 1.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.