Description

n-Boc-3,5-Difluoro-D-Tyrosine is a high-purity, non-natural amino acid derivative designed for advanced pharmaceutical research and development. This compound is a critical chiral building block for the synthesis of complex peptides and peptidomimetics, offering enhanced metabolic stability and binding affinity. It is primarily utilized by medicinal chemists and process development scientists in the pharmaceutical and biotechnology industries for creating novel therapeutic candidates, particularly in oncology and metabolic disease research.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the solid-phase and solution-phase synthesis of fluorinated peptide-based drugs.
• Protease Inhibitor Development: Used in the design and construction of inhibitors targeting specific enzymes, leveraging the fluorine atoms for enhanced binding and selectivity.
• PET (Positron Emission Tomography) Tracer Precursor: Serves as a precursor for radiolabeled compounds used in diagnostic imaging.
• Peptidomimetic Research: Integral for creating stable peptide analogs with improved pharmacokinetic properties for drug discovery programs.
• Chemical Biology Probes: Employed in the synthesis of activity-based probes to study enzyme function and mechanism.
• API (Active Pharmaceutical Ingredient) Development: Used in process chemistry for the scale-up and optimization of novel active ingredients containing fluorinated tyrosine residues.

Basic Information

Product Name	n-Boc-3,5-Difluoro-D-Tyrosine
CAS No.	1213198-51-6
Molecular Formula	C₁₄H₁₇F₂NO₅
Molecular Weight	317.29 g/mol
Synonyms	(2R)-2-[(tert-Butoxycarbonyl)amino]-3-(3,5-difluoro-4-hydroxyphenyl)propanoic acid; D-3,5-Difluorotyrosine, N-Boc-protected; Boc-3,5-Difluoro-D-Tyr-OH; tert-Butyl (R)-2-amino-3-(3,5-difluoro-4-hydroxyphenyl)propanoate; N-(tert-Butoxycarbonyl)-3,5-difluoro-D-tyrosine; Boc-D-3,5-Difluorotyrosine; (R)-2-((tert-Butoxycarbonyl)amino)-3-(3,5-difluoro-4-hydroxyphenyl)propanoic acid
EINECS	Contact for details

Quality Control

Our n-Boc-3,5-Difluoro-D-Tyrosine is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity, chiral HPLC for enantiomeric excess, and NMR for structural confirmation, to ensure it meets the exacting standards required for pharmaceutical R&D. Certificates of Analysis (COA) with full traceability are provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the container to reach room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.