Description

(1R)-2,2,2-Trifluoro-1-(3-Methoxyphenyl)Ethylamine is a high-purity chiral amine building block of significant importance in modern synthetic chemistry. Its core value lies in its trifluoromethyl group and chiral center, which are critical for modulating the biological activity, metabolic stability, and physicochemical properties of advanced molecules. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, serving as a key intermediate in the synthesis of active pharmaceutical ingredients (APIs) and novel crop protection agents.

Application

• As a chiral intermediate in the asymmetric synthesis of pharmaceutical candidates, particularly those targeting central nervous system (CNS) disorders.
• Utilized in the research and development of fluorinated bioactive molecules, where the trifluoromethyl group enhances lipophilicity and metabolic stability.
• Serves as a key building block for constructing ligands and catalysts used in enantioselective transformations.
• Applied in the discovery phase of agrochemicals, such as herbicides and fungicides, leveraging the fluorine atoms for improved efficacy.
• Used in academic and institutional research for methodological studies in organofluorine chemistry and chiral amine synthesis.
• Potential precursor in the development of advanced materials, including liquid crystals and functional polymers.

Basic Information

Product Name	(1R)-2,2,2-Trifluoro-1-(3-Methoxyphenyl)Ethylamine
CAS No.	1213162-90-3
Molecular Formula	C9H10F3NO
Molecular Weight	205.18 g/mol
Synonyms	(R)-1-(3-Methoxyphenyl)-2,2,2-trifluoroethanamine; (1R)-1-(3-Methoxyphenyl)-2,2,2-trifluoroethylamine; (R)-α-(Trifluoromethyl)-3-methoxybenzylamine; (R)-3-Methoxy-α-(trifluoromethyl)benzylamine; (R)-1-(3-Methoxyphenyl)-2,2,2-trifluoroethan-1-amine; (R)-TFMPEA; (R)-Trifluoromethyl-m-anisylamine
EINECS	Contact for details

Quality Control

Our (1R)-2,2,2-Trifluoro-1-(3-Methoxyphenyl)Ethylamine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity analysis by HPLC, to ensure compliance with exacting research and development standards. Comprehensive Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided to guarantee batch-to-batch consistency and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This compound is moisture-sensitive (hygroscopic); keep the container tightly sealed under an inert atmosphere to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.