Description

(1R)-1-(3,4-Difluorophenyl)-2,2,2-Trifluoroethylamine is a high-purity chiral amine building block of significant importance in modern pharmaceutical synthesis. Its value lies in its unique trifluoromethyl and difluorophenyl groups, which are critical for modulating the bioavailability, metabolic stability, and binding affinity of drug candidates. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly those working on central nervous system (CNS) agents, enzyme inhibitors, and novel small-molecule therapeutics.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of novel active pharmaceutical ingredients (APIs), especially in neuropharmacology.
• Agrochemical Research: Used in developing advanced herbicides and pesticides where the fluorine atoms enhance lipophilicity and environmental stability.
• Ligand & Catalyst Development: Serves as a precursor for chiral ligands in asymmetric catalysis, crucial for producing enantiomerically pure compounds.
• Fluorinated Compound Library Synthesis: A valuable building block for medicinal chemistry teams creating focused libraries to explore structure-activity relationships (SAR).
• Material Science Research: Investigated for incorporation into advanced polymers and liquid crystals where fluorine content modifies material properties.

Basic Information

Product Name	(1R)-1-(3,4-Difluorophenyl)-2,2,2-Trifluoroethylamine
CAS No.	1212953-38-2
Molecular Formula	C8H6F5N
Molecular Weight	211.13 g/mol
Synonyms	(R)-1-(3,4-Difluorophenyl)-2,2,2-trifluoroethanamine; (1R)-1-(3,4-Difluorophenyl)-2,2,2-trifluoroethanamine; (R)-α-(3,4-Difluorophenyl)-2,2,2-trifluoroethylamine; (R)-3,4-Difluoro-α-(trifluoromethyl)benzylamine; (R)-1-(3,4-Difluorophenyl)-2,2,2-trifluoroethylamine; (R)-TFMPEA derivative; (R)-Enantiomer of 1-(3,4-Difluorophenyl)-2,2,2-trifluoroethylamine
EINECS	Contact for details

Quality Control

Our (1R)-1-(3,4-Difluorophenyl)-2,2,2-Trifluoroethylamine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC for enantiomeric excess (ee) verification, to ensure compliance with pharmaceutical-grade standards. Comprehensive Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.