Description

(1R)-2-Chloro-1-(3,4-Difluorophenyl)-1-Ethanol CAS NO 1212376-05-0 is a high-purity chiral intermediate characterized by its specific stereochemistry and halogenated aromatic structure. This compound is of significant commercial value for its role in the synthesis of complex, biologically active molecules, where enantiomeric purity is critical for efficacy and safety. It is primarily sought after by pharmaceutical R&D and manufacturing sectors for the development of advanced active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring fluorinated compounds.

Application

• Pharmaceutical Intermediate: A key chiral building block for the synthesis of novel Active Pharmaceutical Ingredients (APIs), especially in central nervous system (CNS) and anti-infective drug candidates.
• Agrochemical Synthesis: Used in the research and production of advanced fluorinated pesticides and herbicides, where the difluorophenyl moiety enhances biological activity and stability.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis to control stereoselectivity.
• Material Science Research: Employed in the development of specialty polymers and liquid crystals, where its fluorinated aromatic structure can modify material properties.
• Academic & Contract Research: A valuable reagent for medicinal chemistry programs and process chemistry optimization in academic and CRO/CMO settings.

Basic Information

Product Name	(1R)-2-Chloro-1-(3,4-Difluorophenyl)-1-Ethanol
CAS No.	1212376-05-0
Molecular Formula	C8H7ClF2O
Molecular Weight	192.59 g/mol
Synonyms	(1R)-2-Chloro-1-(3,4-difluorophenyl)ethanol; (R)-2-Chloro-1-(3,4-difluorophenyl)ethanol; (R)-2-Chloro-1-(3,4-difluorophenyl)ethan-1-ol; 1-(3,4-Difluorophenyl)-2-chloro-1-ethanol, (1R)-; (R)-1-(3,4-Difluorophenyl)-2-chloroethanol; (R)-α-(Chloromethyl)-3,4-difluorobenzyl alcohol
EINECS	Contact for details

Quality Control

Our (1R)-2-Chloro-1-(3,4-Difluorophenyl)-1-Ethanol is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including chiral HPLC to ensure high enantiomeric excess (ee) and purity. We provide full traceability and Certificates of Analysis (COA) are available for every shipment, detailing identity, assay, impurity profile, and chiral purity. Our quality commitment aligns with cGMP and ISO standards for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound may be hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere if necessary. Keep away from strong oxidizing agents and bases.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Total impurities ≤ 1.0% Any single impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.