Description

cis-2-(((9H-Fluoren-9-Yl)Methoxy)Carbonylamino)Cyclopent-3-Ene-1-Carboxylic Acid is a specialized Fmoc-protected amino acid derivative, a critical building block in modern synthetic chemistry. Its primary value lies in enabling the precise, sequential construction of complex peptides and peptidomimetics under standard solid-phase peptide synthesis (SPPS) conditions. This compound is essential for researchers and manufacturers in pharmaceutical development, particularly for creating novel therapeutic peptides, and in biochemical research for probing protein structure and function.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key Fmoc-protected intermediate for the controlled incorporation of a constrained cyclopentene amino acid into peptide chains.
• Pharmaceutical Research & Development: Synthesis of peptide-based drug candidates, including enzyme inhibitors, receptor agonists/antagonists, and diagnostic agents.
• Peptidomimetic Design: Introduction of conformational constraints and structural diversity into peptide backbones to enhance metabolic stability, bioavailability, and binding affinity.
• Chemical Biology & Proteomics: Tool for site-specific labeling, cross-linking studies, and the synthesis of custom peptides for biological assays.
• Academic Research: Fundamental studies in organic synthesis, medicinal chemistry, and peptide science.

Basic Information

Product Name	cis-2-(((9H-Fluoren-9-Yl)Methoxy)Carbonylamino)Cyclopent-3-Ene-1-Carboxylic Acid
CAS No.	1212278-30-2
Molecular Formula	C21H19NO5
Molecular Weight	365.38 g/mol
Synonyms	Fmoc-2-amino-3-cyclopentene-1-carboxylic acid (cis); (1S,2R)-2-[[(9H-Fluoren-9-ylmethoxy)carbonyl]amino]cyclopent-3-ene-1-carboxylic acid; Fmoc-cis-2-Ac3c-OH; cis-2-(Fmoc-amino)cyclopent-3-ene-1-carboxylic acid; 2-[[(9H-Fluoren-9-ylmethoxy)carbonyl]amino]-3-cyclopentene-1-carboxylic acid; Fmoc-(cis)-2-amino-1-cyclopentene-1-carboxylic acid; Fmoc-Acp(3,4-cis)-OH; Fmoc-protected cyclopentenyl glycine analog
EINECS	Contact for details

Quality Control

Our production of this advanced pharmaceutical intermediate adheres to stringent quality protocols. Every batch undergoes comprehensive analytical characterization, including HPLC for purity and NMR for structural confirmation, to ensure consistency and reliability for critical research and development applications. Certificates of Analysis (COA) detailing identity, purity (typically >95% by HPLC), and impurity profiles are provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed and consideration should be given to storage under an inert atmosphere for long-term preservation of quality. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.