Description

(S)-n-Fmoc-4,4,4,4,4,4-Hexafluorovaline CAS NO 1212153-68-8 is a high-purity, non-natural amino acid derivative featuring a hexafluorinated side chain, protected with an Fmoc (9-fluorenylmethoxycarbonyl) group. This compound is critically important for the synthesis of fluorinated peptides and peptidomimetics, where the introduction of fluorine atoms dramatically enhances metabolic stability, lipophilicity, and binding affinity. It is an essential building block for pharmaceutical research and development, particularly in medicinal chemistry for creating novel drug candidates, as well as in advanced materials science.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid for the automated synthesis of fluorinated peptides in drug discovery.
• Medicinal Chemistry & Drug Design: Used to incorporate hexafluorovaline residues into lead compounds to improve their pharmacokinetic properties, such as membrane permeability and proteolytic resistance.
• Bioconjugation & Probe Development: Serves as a precursor for creating fluorinated tags and probes used in biochemical assays and imaging studies.
• Peptidomimetic Research: Essential for constructing non-natural peptide backbones that mimic natural protein structures with enhanced stability.
• Pharmaceutical Intermediate: A critical raw material in the multi-step synthesis of complex active pharmaceutical ingredients (APIs) targeting various diseases.
• Academic & Institutional Research: Used in universities and research institutes for studying the effects of fluorination on protein folding and function.

Basic Information

Product Name	(S)-n-Fmoc-4,4,4,4,4,4-Hexafluorovaline
CAS No.	1212153-68-8
Molecular Formula	C₂₁H₁₇F₆NO₄
Molecular Weight	461.36 g/mol
Synonyms	Fmoc-(S)-Hexafluorovaline; Fmoc-HFV-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-4,4,4,4,4,4-hexafluoro-L-valine; (S)-2-(((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3,3-bis(trifluoromethyl)butanoic acid; N-α-Fmoc-4,4,4,4,4,4-hexafluoro-L-valine; Fmoc-L-Hexafluorovaline; Fmoc-4,4,4,4,4,4-HFV; Boc-HFV-OH (related protected form)
EINECS	Contact for details

Quality Control

Our (S)-n-Fmoc-4,4,4,4,4,4-Hexafluorovaline is manufactured under strict quality control protocols to ensure the high purity and consistency required for sensitive pharmaceutical research. Each batch is analyzed using advanced chromatographic and spectroscopic techniques. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided and available upon request, supporting compliance with internal quality standards for research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥ 98.0%
Optical Rotation [α]²⁰D	Contact for details
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 10 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.