Description

5-Bromo-4-Chloro-2-(Trifluoromethyl)Pyrimidine is a high-value, multi-halogenated pyrimidine building block essential for advanced organic synthesis. Its unique structure, featuring bromo, chloro, and trifluoromethyl substituents, makes it a critical intermediate for introducing specific steric and electronic properties into target molecules. This compound is primarily utilized by pharmaceutical and agrochemical R&D teams for the development of novel active ingredients, including kinase inhibitors and crop protection agents.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of small molecule drug candidates, particularly kinase inhibitors and other targeted therapies.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides, leveraging the bioactivity of the halogenated pyrimidine core.
• Material Science Precursor: Serves as a building block for creating functionalized polymers and liquid crystals with tailored electronic properties.
• Cross-Coupling Reactions: The bromo substituent is an excellent handle for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira) to create complex biaryl systems.
• Nucleophilic Substitution: The chloro group allows for further functionalization via nucleophilic aromatic substitution, enabling diverse chemical modifications.
• Fluorine Chemistry: The trifluoromethyl group is a valuable source of fluorine, imparting enhanced metabolic stability, lipophilicity, and bioavailability to final compounds.

Basic Information

Product Name	5-Bromo-4-Chloro-2-(Trifluoromethyl)Pyrimidine
CAS No.	1211586-58-1
Molecular Formula	C5H2BrClF3N2
Molecular Weight	271.43 g/mol
Synonyms	4-Chloro-5-bromo-2-(trifluoromethyl)pyrimidine; 2-(Trifluoromethyl)-5-bromo-4-chloropyrimidine; 5-Bromo-4-chloro-2-trifluoromethylpyrimidine; Pyrimidine, 5-bromo-4-chloro-2-(trifluoromethyl)-; 1211586-58-1
EINECS	Contact for details

Quality Control

Our 5-Bromo-4-Chloro-2-(Trifluoromethyl)Pyrimidine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for research and development. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from incompatible materials such as strong bases and reducing agents. The compound is moisture-sensitive; keep the container tightly sealed in a dry environment.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.