Description

4'-(Trifluoromethyl)-[1,1'-Biphenyl]-3-Amine Hydrochloride, also known as 4-(3-Aminophenyl)Benzotrifluoride Hydrochloride or 3-[4-(Trifluoromethyl)Phenyl]Aniline Hydrochloride, is a high-purity, functionalized aniline derivative of significant importance in advanced organic synthesis. This compound serves as a critical building block for the development of pharmaceuticals, agrochemicals, and specialty materials, where the trifluoromethyl and biphenyl motifs are key to modulating biological activity and material properties. It is primarily sought by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those targeting central nervous system (CNS) disorders, inflammation, and oncology.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances lipophilicity and metabolic stability.
• Liquid Crystal & OLED Materials: Serves as a core structure in the synthesis of specialty chemicals for electronic displays and organic light-emitting diodes (OLEDs).
• Polymer & Resin Modifier: Incorporated into polymer chains to impart specific thermal, chemical, or surface properties.
• Cross-coupling Reactions: Utilized as a versatile substrate in Suzuki, Buchwald-Hartwig, and other palladium-catalyzed cross-coupling reactions to construct complex biaryl systems.
• Dye & Pigment Intermediate: Acts as a starting material for the production of specialized dyes and pigments.
• Research & Development: Essential for medicinal chemistry programs and material science research in academic and industrial laboratories.

Basic Information

Product Name	4'-(Trifluoromethyl)-[1,1'-Biphenyl]-3-Amine Hydrochloride
CAS No.	1211195-38-8
Molecular Formula	C13H10F3N • HCl
Molecular Weight	273.68 g/mol
Synonyms	4-(3-Aminophenyl)Benzotrifluoride Hydrochloride; 3-[4-(Trifluoromethyl)Phenyl]Aniline Hydrochloride; [1,1'-Biphenyl]-3-amine, 4'-(trifluoromethyl)-, hydrochloride; 3-Amino-4'-trifluoromethylbiphenyl Hydrochloride; 4'-Trifluoromethylbiphenyl-3-ylamine Hydrochloride; 3-(4-Trifluoromethylphenyl)aniline hydrochloride; 4-(3-Aminophenyl)(trifluoromethyl)benzene hydrochloride
EINECS	Contact for details

Quality Control

Our 4'-(Trifluoromethyl)-[1,1'-Biphenyl]-3-Amine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and consistent quality suitable for demanding synthetic applications. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; containers must be kept tightly sealed and away from moisture and direct light to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.