Description

Fmoc-n-Me-D-Ser(Tbu)-Oh is a protected, non-natural amino acid derivative used in solid-phase peptide synthesis (SPPS). This compound matters as a critical building block for introducing N-methylated D-serine residues into peptide chains, a modification that enhances metabolic stability and modulates biological activity. It is primarily needed by pharmaceutical R&D teams, biotech companies, and CROs engaged in the development of novel therapeutic peptides, peptidomimetics, and peptide-based drug candidates.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key Fmoc-protected amino acid for the automated synthesis of complex peptides.
• Therapeutic Peptide Development: For incorporating N-methyl-D-serine into sequences to improve proteolytic stability, membrane permeability, and pharmacokinetic profiles.
• Peptidomimetic Research: Serving as a scaffold for creating conformationally constrained analogs in drug discovery programs.
• Antibiotic & Antimicrobial Peptide Design: Used to engineer novel peptide antibiotics with enhanced efficacy and reduced susceptibility to degradation.
• GPCR-Targeting Ligands: In the synthesis of peptide hormones and neuropeptides targeting G-protein-coupled receptors.
• Bioconjugation & Labeling: As a specialty amino acid for introducing unique handles or modifying peptide properties for diagnostic or targeting applications.

Basic Information

Product Name	Fmoc-n-Me-D-Ser(Tbu)-Oh
CAS No.	1210833-53-6
Molecular Formula	C23H27NO5
Molecular Weight	397.47 g/mol
Synonyms	Fmoc-N-methyl-D-serine(t-butyl) ether; Fmoc-N-Me-D-Ser(OtBu)-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-N-methyl-D-serine tert-butyl ester; (R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)(methyl)amino)-3-((tert-butoxy)oxy)propanoic acid; Fmoc-N-Me-D-Ser(Tbu)-OH; Fmoc-N-Me-D-Ser(OtBu)-OH; N-Fmoc-N-methyl-D-O-tert-butylserine; Fmoc-D-N-methylserine(O-t-butyl)
EINECS	Contact for details

Quality Control

Our Fmoc-n-Me-D-Ser(Tbu)-Oh is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral integrity, to ensure compliance with exacting standards for peptide synthesis. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee batch-to-batch consistency and suitability for sensitive R&D and cGMP applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label or COA. This material is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% D-isomer
Water Content (KF)	≤0.5%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.