Description

n-Fmoc-(R)-2-(Methylamino)Butyric Acid CAS NO 1210830-60-6 is a high-purity, non-natural amino acid derivative featuring an Fmoc-protected amine group and a methylamino side chain. This compound is a critical chiral building block for the solid-phase peptide synthesis (SPPS) of complex peptides and peptidomimetics, enabling precise control over stereochemistry and side-chain functionality. It is primarily utilized by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers developing novel therapeutic peptides, diagnostic agents, and bioactive compounds.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key chiral intermediate for the automated synthesis of custom peptides with specific (R)-configuration at the α-carbon.
• Pharmaceutical Research: Used in the discovery and development of peptide-based drugs, including hormone analogs, enzyme inhibitors, and targeted therapeutics.
• Peptidomimetic Design: Incorporates non-natural amino acid structures into molecules to enhance metabolic stability, bioavailability, and binding affinity.
• Bioconjugation & Labeling: Serves as a precursor for creating labeled peptides or peptide-drug conjugates for diagnostic and research applications.
• Chemical Biology Probes: Employed in the synthesis of specialized peptides used to study protein-protein interactions and cellular pathways.
• Academic & Industrial R&D: Essential raw material for laboratories focused on organic synthesis, medicinal chemistry, and peptide science.

Basic Information

Product Name	n-Fmoc-(R)-2-(Methylamino)Butyric Acid
CAS No.	1210830-60-6
Molecular Formula	C₂₁H₂₃NO₄
Molecular Weight	353.41 g/mol
Synonyms	(R)-2-(9H-Fluoren-9-ylmethoxy)carbonylamino]butanoic Acid; Fmoc-N-Me-(R)-Abu-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-N-methyl-D-homoalanine; N-α-Fmoc-N-α-methyl-D-homoalanine; Fmoc-N-methyl-D-2-aminobutanoic Acid; N-Fmoc-N-methyl-D-norvaline; Fmoc-Me-D-Abu-OH
EINECS	Contact for details

Quality Control

Every batch of n-Fmoc-(R)-2-(Methylamino)Butyric Acid is manufactured under strict quality management systems and undergoes comprehensive analytical testing. We provide full traceability and Certificates of Analysis (COA) detailing purity, chiral purity, and impurity profiles to ensure compliance with research and pharmaceutical-grade standards. Our quality protocols are designed to meet the stringent requirements of advanced peptide synthesis applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the sealed container to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% (R-isomer)
Water Content (KF)	≤0.5%
Heavy Metals	≤10 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.