Description

3'-Fluoro-[1,1'-Biphenyl]-3-Amine Hydrochloride is a high-purity, functionalized biphenyl derivative used as a critical building block in advanced organic synthesis. This compound matters because it provides a versatile aromatic amine scaffold with a fluorine substituent, enabling precise molecular design for active pharmaceutical ingredients and specialty materials. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for creating novel compounds with targeted properties.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, inflammation, and oncology.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and pesticides, where the fluorine atom and biphenyl core can enhance biological activity and environmental stability.
• Liquid Crystal & OLED Materials: Acts as a functional unit in the synthesis of advanced electronic materials for displays and lighting, leveraging its rigid biphenyl structure and fluorine's electronic effects.
• Polymer Chemistry: Employed as a monomer or cross-linking agent to introduce aromatic amine functionality into specialty polymers, resins, and coatings.
• Chemical Biology & Proteomics: Utilized as a tagging or labeling reagent in biochemical assays and probe development due to its amine handle for conjugation.
• Academic & Contract Research: A valuable reagent for methodological development and exploration of novel fluorinated aromatic reaction pathways in academic and CRO settings.

Basic Information

Product Name	3'-Fluoro-[1,1'-Biphenyl]-3-Amine Hydrochloride
CAS No.	1210215-22-7
Molecular Formula	C12H11ClFN
Molecular Weight	223.67 g/mol
Synonyms	3'-Fluoro-3-biphenylamine hydrochloride; 3-Amino-3'-fluorobiphenyl hydrochloride; [1,1'-Biphenyl]-3-amine, 3'-fluoro-, hydrochloride (1:1); 3'-Fluoro-[1,1'-biphenyl]-3-amine HCl; 3-(3-Fluorophenyl)aniline hydrochloride; 3'-Fluorobiphenyl-3-amine hydrochloride; 3-Fluoro-3'-aminobiphenyl hydrochloride
EINECS	Contact for details

Quality Control

Our 3'-Fluoro-[1,1'-Biphenyl]-3-Amine Hydrochloride is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. For long-term storage, consider using desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.