Description

1-(2,5-Difluorophenyl)Cyclopropanamine Hydrochloride is a high-purity, fluorinated cyclopropylamine building block essential for modern pharmaceutical and agrochemical research. This compound serves as a critical intermediate in the synthesis of novel active pharmaceutical ingredients (APIs) and crop protection agents, enabling the introduction of the unique steric and electronic properties of the cyclopropylamine moiety. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries seeking to develop new molecules with enhanced biological activity and metabolic stability.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly in central nervous system (CNS) and oncology research.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides that leverage fluorine chemistry for improved efficacy.
• Chemical Biology & Proteomics: Serves as a versatile scaffold for creating molecular probes and enzyme inhibitors for target validation studies.
• Material Science Research: Potential precursor for specialty polymers and advanced materials requiring fluorinated aromatic components.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for use in client-directed synthesis projects at various scales, from gram to kilogram.

Basic Information

Product Name	1-(2,5-Difluorophenyl)Cyclopropanamine Hydrochloride
CAS No.	1209947-02-3
Molecular Formula	C9H9F2N • HCl
Molecular Weight	205.63 (Free base) / 242.09 (HCl salt)
Synonyms	1-(2,5-Difluorophenyl)cyclopropanamine hydrochloride; 1-(2,5-Difluorophenyl)cyclopropan-1-amine HCl; 2,5-Difluoro-α-(cyclopropylamino)benzene hydrochloride; Cyclopropanamine, 1-(2,5-difluorophenyl)-, hydrochloride; 1209947-02-3; 1-(2,5-Difluorophenyl)cyclopropylamine hydrochloride
EINECS	Contact for details

Quality Control

Our 1-(2,5-Difluorophenyl)Cyclopropanamine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, confirming compliance with customer specifications. Our quality commitment supports applications requiring material for GLP (Good Laboratory Practice) and non-GMP pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.