Description

1H-Indole, 7-Fluoro-4-(Trifluoromethoxy)- is a high-value, multi-functionalized indole derivative, serving as a critical advanced intermediate in modern organic synthesis. Its unique structure, featuring both fluorine and trifluoromethoxy substituents, is engineered to impart enhanced metabolic stability, lipophilicity, and binding affinity in target molecules. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, where it is used to construct novel active ingredients. Its precise synthesis and high purity are paramount for successful downstream applications.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel drug candidates, particularly in oncology, CNS disorders, and anti-inflammatory therapies, leveraging the bioisosteric properties of fluorine.
• Agrochemical Research: Used in developing next-generation herbicides, fungicides, and insecticides, where the trifluoromethoxy group can enhance biological activity and environmental profile.
• Material Science Precursor: Serves as a specialty monomer or functional additive in the development of advanced organic electronic materials, such as OLEDs or conductive polymers.
• Chemical Biology Probe: Utilized in medicinal chemistry to create molecular probes for studying enzyme mechanisms and protein-ligand interactions.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs and research institutions for bespoke synthesis projects requiring complex, fluorinated heterocycles.

Basic Information

Product Name	1H-Indole, 7-Fluoro-4-(Trifluoromethoxy)-
CAS No.	1208977-14-3
Molecular Formula	C9H5F4NO
Molecular Weight	219.14 g/mol
Synonyms	7-Fluoro-4-(trifluoromethoxy)-1H-indole; 4-(Trifluoromethoxy)-7-fluoroindole; 7-Fluoro-4-trifluoromethoxyindole; 1H-Indole, 7-fluoro-4-(trifluoromethoxy)-; 1208977-14-3; 7-Fluoro-4-(trifluoromethoxy)indole; 4-Trifluoromethoxy-7-fluoroindole
EINECS	Contact for details

Quality Control

Every batch of 1H-Indole, 7-Fluoro-4-(Trifluoromethoxy)- is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, GC, NMR, and MS, to ensure identity, purity, and consistency meet the exacting standards required for advanced synthetic applications. Certificates of Analysis (COA) detailing all specifications are provided with each shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (typically 15-25°C). This compound is light-sensitive (store away from light) and should be handled under an inert atmosphere for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.