Description

2'-(Trifluoromethyl)-[1,1'-Biphenyl]-2-Amine Hydrochloride is a high-purity, advanced pharmaceutical intermediate characterized by its biphenyl core and trifluoromethyl substituent. This compound is critical for medicinal chemistry research and development, serving as a key building block in the synthesis of novel active pharmaceutical ingredients (APIs). It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for creating compounds with enhanced metabolic stability and bioavailability.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, particularly in oncology and central nervous system (CNS) therapeutic areas.
• Agrochemical Synthesis: Used in the development of advanced pesticides and herbicides, where the trifluoromethyl group can improve biological activity and environmental stability.
• Material Science Research: Serves as a precursor for organic electronic materials and liquid crystals due to its rigid biphenyl structure.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes for studying biological pathways and target engagement.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) producing bespoke compounds for clients.

Basic Information

Product Name	2'-(Trifluoromethyl)-[1,1'-Biphenyl]-2-Amine Hydrochloride
CAS No.	1208620-12-5
Molecular Formula	C13H11ClF3N
Molecular Weight	273.68 g/mol
Synonyms	2-Amino-2'-(trifluoromethyl)biphenyl hydrochloride; [1,1'-Biphenyl]-2-amine, 2'-(trifluoromethyl)-, hydrochloride; 2'-(Trifluoromethyl)biphenyl-2-amine HCl; 2-(Trifluoromethyl)-[1,1'-biphenyl]-2-amine hydrochloride; 2'-Trifluoromethyl-2-aminobiphenyl hydrochloride; 2-Amino-2'-trifluoromethylbiphenyl hydrochloride; (2'-Trifluoromethyl-biphenyl-2-yl)-amine hydrochloride
EINECS	Contact for details

Quality Control

Our 2'-(Trifluoromethyl)-[1,1'-Biphenyl]-2-Amine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for your most demanding R&D and scale-up projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.