Description

4-Bromo-2-(Methylsulfonyl)Pyrimidine is a high-purity pyrimidine derivative, a versatile and critical building block in modern organic synthesis. Its unique structure, featuring both bromo and methylsulfonyl functional groups, makes it an essential intermediate for constructing complex molecules with specific electronic and steric properties. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, leveraging its reactivity for structural diversification.
• Material Science Research: Serves as a building block for creating organic electronic materials, such as ligands for metal-organic frameworks (MOFs) or components in organic semiconductors.
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to form biaryl systems.
• Nucleophilic Substitution: The methylsulfonyl group is a good leaving group, enabling further functionalization of the pyrimidine ring through nucleophilic aromatic substitution.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes for studying biological pathways and target engagement.

Basic Information

Product Name	4-Bromo-2-(Methylsulfonyl)Pyrimidine
CAS No.	1208538-52-6
Molecular Formula	C5H5BrN2O2S
Molecular Weight	237.07 g/mol
Synonyms	4-Bromo-2-(methylsulfonyl)pyrimidine; 2-(Methylsulfonyl)-4-bromopyrimidine; 4-Bromo-2-methanesulfonylpyrimidine; Pyrimidine, 4-bromo-2-(methylsulfonyl)-; 1208538-52-6; 4-Bromo-2-methylsulfonylpyrimidine
EINECS	Contact for details

Quality Control

Our 4-Bromo-2-(Methylsulfonyl)Pyrimidine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment supports applications in cGMP and ISO-compliant environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. The product is light-sensitive and should be stored away from light.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.