Description

4,6-Dichloro-5-Iodopyrimidin-2-Amine is a high-value halogenated pyrimidine building block essential for advanced organic synthesis. This compound matters as a versatile intermediate for constructing complex molecules, particularly in pharmaceutical research and development. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of nucleoside analogs, kinase inhibitors, and other small molecule APIs.
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and plant growth regulators.
• Chemical Biology: Serves as a precursor for labeled compounds and molecular probes in biochemical studies.
• Material Science: Intermediate for the synthesis of specialty polymers and liquid crystals.
• Cross-Coupling Reactions: The iodine and chlorine substituents make it an excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions.
• Nucleic Acid Chemistry: Used in the preparation of modified nucleobases and oligonucleotides.

Basic Information

Product Name	4,6-Dichloro-5-Iodopyrimidin-2-Amine
CAS No.	1208108-99-9
Molecular Formula	C4H2Cl2IN3
Molecular Weight	305.89 g/mol
Synonyms	2-Amino-4,6-dichloro-5-iodopyrimidine; 5-Iodo-4,6-dichloropyrimidin-2-amine; 4,6-Dichloro-5-iodo-2-pyrimidinamine; 4,6-Dichloro-5-iodopyrimidin-2-ylamine; 2-Pyrimidinamine, 4,6-dichloro-5-iodo-; DCIP; 5-Iodo-4,6-dichloro-2-aminopyrimidine
EINECS	Contact for details

Quality Control

Our 4,6-Dichloro-5-Iodopyrimidin-2-Amine is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity for research and development applications. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing purity, identity, and impurity profiles. Our quality systems are designed to support cGMP requirements for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed and under a dry inert atmosphere for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC/IR)	Conforms
Assay (HPLC)	≥97.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Single Unknown Impurity (HPLC)	≤0.5%
Total Impurities (HPLC)	≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.