Description

2-Amino-4-{4-Chloro-2-[2-(4-Fluoropyrazol-1-Yl)Ethoxy]-6-Methylphenyl}-5,7-Dihydropyrrolo[3,4-D]Pyrimidine-6-Carboxylic Acid (2,2-Difluoropropyl)Amide is a high-purity, advanced pharmaceutical intermediate with a complex heterocyclic structure. This compound is of significant value for its role as a key building block in the synthesis of novel, targeted therapeutic agents. It is primarily required by research institutions and pharmaceutical companies engaged in the development of small-molecule drugs, particularly in oncology and other specialized therapeutic areas.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the multi-step synthesis of investigational new drugs (INDs) and new chemical entities (NCEs).
• Oncology Drug Discovery: Used in research programs focused on developing kinase inhibitors and other targeted cancer therapies due to its pyrrolopyrimidine core.
• Medicinal Chemistry Research: Employed as a scaffold for structure-activity relationship (SAR) studies and lead optimization in academic and industrial R&D labs.
• Process Chemistry Development: Utilized for scaling up synthetic routes from milligram to kilogram scale under current Good Manufacturing Practice (cGMP) guidelines.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of clinical trial materials.
• Biochemical Tool Compound: Potential use in biochemical assays to study specific enzyme interactions and cellular pathways.

Basic Information

Product Name	2-Amino-4-{4-Chloro-2-[2-(4-Fluoropyrazol-1-Yl)Ethoxy]-6-Methylphenyl}-5,7-Dihydropyrrolo[3,4-D]Pyrimidine-6-Carboxylic Acid (2,2-Difluoropropyl)Amide
CAS No.	1207961-33-8
Molecular Formula	C22H22ClF3N6O2
Molecular Weight	494.90 g/mol
Synonyms	1207961-33-8; 2-Amino-4-[4-chloro-2-[2-(4-fluoropyrazol-1-yl)ethoxy]-6-methylphenyl]-5,7-dihydro-6H-pyrrolo[3,4-d]pyrimidine-6-carboxylic acid 2,2-difluoropropylamide; (2,2-Difluoropropyl){2-amino-4-[4-chloro-2-(2-(4-fluoropyrazol-1-yl)ethoxy)-6-methylphenyl]-5,7-dihydro-6H-pyrrolo[3,4-d]pyrimidin-6-yl}methanone; PF-06463922 Intermediate; Lorlatinib Intermediate; ALK/ROS1 Inhibitor Intermediate.
EINECS	Contact for details

Quality Control

Our 2-Amino-4-{4-Chloro-2-[2-(4-Fluoropyrazol-1-Yl)Ethoxy]-6-Methylphenyl}-5,7-Dihydropyrrolo[3,4-D]Pyrimidine-6-Carboxylic Acid (2,2-Difluoropropyl)Amide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Production can be aligned with cGMP standards for advanced pharmaceutical applications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is light-sensitive and should be handled under inert atmosphere when appropriate for long-term stability. Keep container tightly sealed in a dry environment to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.