Description

Tetrahydrofuran-3-Sulfonyl Chloride, 97% is a high-purity sulfonyl chloride derivative featuring a tetrahydrofuran ring, making it a versatile and reactive building block for organic synthesis. This compound is valued for its role as a key sulfonylation reagent, enabling the introduction of the sulfonyl functional group into target molecules. It is primarily utilized by researchers and process chemists in the pharmaceutical, agrochemical, and specialty chemical industries for the development of new active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: A critical reagent in the synthesis of sulfonamide-based drug candidates, including protease inhibitors and receptor antagonists.
• Agrochemical Synthesis: Used in the preparation of novel herbicides, fungicides, and insecticides that incorporate sulfonyl moieties for enhanced activity.
• Polymer Chemistry: Serves as a monomer or cross-linking agent in the production of specialty polymers and functional materials.
• Chemical Research & Development: Employed in medicinal chemistry and process development for structure-activity relationship (SAR) studies and route scouting.
• Ligand and Catalyst Preparation: Useful for modifying ligands and catalysts to tune their properties in catalytic reactions.
• Peptide Modification: Applied in bioconjugation chemistry to modify peptides and proteins.

Basic Information

Product Name	Tetrahydrofuran-3-Sulfonyl Chloride, 97%
CAS No.	1207346-29-9
Molecular Formula	C4H7ClO3S
Molecular Weight	170.61 g/mol
Synonyms	3-Thiophenecarboxylic acid, tetrahydro-, sulfonyl chloride; Tetrahydro-3-furansulfonyl chloride; 3-Sulfonylchloride-tetrahydrofuran; THF-3-sulfonyl chloride; Oxolane-3-sulfonyl chloride; 3-(Chlorosulfonyl)oxolane; Tetrahydrofuran-3-sulfonic acid chloride
EINECS	Contact for details

Quality Control

Our Tetrahydrofuran-3-Sulfonyl Chloride, 97% is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and titration methods, to ensure it meets the declared purity and specification. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to prevent decomposition. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.