Description

4-Ethynylpyrimidin-2-Amine (CAS NO 1207175-18-5) is a high-value pyrimidine derivative featuring a reactive ethynyl group, making it a versatile and critical building block in advanced organic synthesis. Its primary value lies in its role as a key intermediate for constructing complex molecular architectures, particularly in pharmaceutical research and development. This compound is essential for medicinal chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries seeking to develop new active compounds.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of kinase inhibitors and other targeted therapeutic agents.
• Agrochemical Research: Used in developing novel active ingredients for crop protection products.
• Chemical Biology & Proteomics: Serves as a click chemistry handle (via the alkyne group) for bioconjugation and probe development.
• Material Science: Acts as a monomer or cross-linking agent in the development of specialty polymers and advanced materials.
• Academic & Contract Research: Employed in discovery chemistry for constructing diverse heterocyclic libraries.
• Process Chemistry: Used in scaling up routes for active pharmaceutical ingredients (APIs) requiring the pyrimidin-2-amine scaffold.

Basic Information

Product Name	4-Ethynylpyrimidin-2-Amine
CAS No.	1207175-18-5
Molecular Formula	C6H5N3
Molecular Weight	119.12 g/mol
Synonyms	2-Amino-4-ethynylpyrimidine; 4-Ethynyl-2-pyrimidinamine; 4-Ethynylpyrimidin-2-ylamine; 2-Pyrimidinamine, 4-ethynyl-; 4-Ethynyl-2-aminopyrimidine; 4-Ethynyl-2-pyrimidineamine
EINECS	Contact for details

Quality Control

Every batch of 4-Ethynylpyrimidin-2-Amine is produced and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for research and development. A Certificate of Analysis (COA) detailing purity (typically ≥95% by HPLC), identity confirmation, and impurity profile is supplied with each shipment to guarantee batch-to-batch consistency and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.