Description

β-Amyloid (22-40) CAS NO 1206779-25-0 is a specific peptide fragment derived from the amyloid precursor protein (APP), representing a key sequence involved in amyloidogenic processing. This compound is of significant value as a critical research tool for studying the aggregation mechanisms, neurotoxicity, and structural biology of amyloid-beta peptides, which are central to Alzheimer's disease pathology. It is primarily needed by researchers and developers in the fields of neuroscience, pharmaceutical discovery, and diagnostic assay development for advancing therapeutic and diagnostic strategies.

Application

• Neuroscience Research: Used as a standard or substrate to investigate the aggregation kinetics, fibril formation, and oligomerization pathways of amyloid-beta peptides.
• Drug Discovery Screening: Serves as a target molecule in high-throughput assays to identify and evaluate potential inhibitors of Aβ aggregation or toxicity.
• Biochemical Assay Development: Employed in the development and validation of ELISA, Western blot, or other immunoassays for detecting specific Aβ epitopes.
• Structural Biology Studies: Utilized in NMR, X-ray crystallography, or electron microscopy to determine the three-dimensional structure of Aβ fragments.
• Toxicity & Mechanism Studies: Applied in cell culture and animal models to study the specific neurotoxic effects and signaling pathways induced by Aβ(22-40).
• Antibody Production & Characterization: Acts as an immunogen or antigen for generating and testing the specificity of antibodies against the Aβ region.

Basic Information

Item	Details
Product Name	β-Amyloid (22-40)
CAS No.	1206779-25-0
Molecular Formula	C87H131N25O26S
Molecular Weight	1975.2 g/mol
Synonyms	Amyloid β-Protein (22-40); Aβ(22-40); β-Amyloid Peptide (22-40); Amyloid β (22-40); APP (672-690); DAEFRHDSGYEVHHQKLVFF
EINECS	Contact for details

Quality Control

Our β-Amyloid (22-40) is produced under stringent conditions to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot undergoes comprehensive analytical characterization, including purity assessment by HPLC and identity confirmation by mass spectrometry. Certificates of Analysis (COA) detailing all specifications and test results are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccation. Allow the vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 70%
Molecular Weight	1975.2 ± 2.0 Da
Solubility	Soluble in water or dilute acetic acid

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.