Description

1-((2R,3R,4R,5S)-3,4-Dihydroxy-5-(Iodomethyl)-3-Methyltetrahydrofuran-2-Yl)Pyrimidine-2,4(1H,3H)-Dione is a high-purity, stereochemically defined nucleoside analog intermediate of significant interest in advanced pharmaceutical research and development. This compound is critical for the synthesis of novel antiviral and anticancer agents, where precise molecular configuration is paramount for biological activity. It serves as a key building block for medicinal chemists and process development scientists in the pharmaceutical and biotechnology industries, enabling the creation of next-generation therapeutics.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of modified nucleoside analogs for antiviral and anticancer drug candidates.
• Antiviral Drug Development: Used in research targeting viruses such as hepatitis and other RNA-based pathogens.
• Oncology Research: Serves as a building block for prodrugs and targeted therapies designed to disrupt cancer cell DNA/RNA synthesis.
• Medicinal Chemistry: Enables structure-activity relationship (SAR) studies to optimize the potency and selectivity of new chemical entities.
• Process Chemistry & Scale-up: Supports the development of robust, scalable synthetic routes for active pharmaceutical ingredients (APIs).
• Biochemical Research: Acts as a substrate or inhibitor in enzymatic studies to understand nucleic acid metabolism.

Basic Information

Product Name	1-((2R,3R,4R,5S)-3,4-Dihydroxy-5-(Iodomethyl)-3-Methyltetrahydrofuran-2-Yl)Pyrimidine-2,4(1H,3H)-Dione
CAS No.	1206126-39-7
Molecular Formula	C10H13IN2O6
Molecular Weight	384.12 g/mol
Synonyms	5'-Deoxy-5'-iodo-3'-O-methyluridine; 5'-Iodo-5'-deoxy-3'-O-methyluridine; 1-[(2R,3R,4R,5S)-3,4-Dihydroxy-5-(iodomethyl)-3-methyloxolan-2-yl]pyrimidine-2,4-dione; 3'-O-Methyl-5'-iodo-5'-deoxyuridine; 5'-Deoxy-5'-iodo-3'-methyluridine; (2R,3R,4R,5S)-2-(2,4-Dioxo-3,4-dihydropyrimidin-1(2H)-yl)-5-(iodomethyl)-3-methyltetrahydrofuran-3,4-diol
EINECS	Contact for details

Quality Control

Our 1-((2R,3R,4R,5S)-3,4-Dihydroxy-5-(Iodomethyl)-3-Methyltetrahydrofuran-2-Yl)Pyrimidine-2,4(1H,3H)-Dione is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification, to ensure it meets the exacting standards required for pharmaceutical R&D. A detailed Certificate of Analysis (COA) providing identity, purity (HPLC), and impurity profile is supplied with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is light-sensitive (store away from light). For long-term storage, consider storing under inert atmosphere at lower temperatures (e.g., -20°C). Keep the container tightly sealed in a dry environment to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.