Description

2-Ethynyl-5-Fluoro-Pyrimidine is a high-value fluorinated pyrimidine derivative featuring a reactive ethynyl group. This compound serves as a critical advanced pharmaceutical intermediate for the synthesis of novel active pharmaceutical ingredients (APIs). It is primarily utilized by pharmaceutical R&D and fine chemical synthesis teams developing targeted therapies.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel small-molecule drugs, particularly in oncology and antiviral research.
• Agrochemical Synthesis: Used in the development of advanced pesticides and herbicides due to its fluorinated pyrimidine core.
• Material Science Research: Serves as a monomer or precursor for creating specialized polymers and organic electronic materials.
• Cross-Coupling Reactions: The ethynyl group enables efficient Sonogashira and other palladium-catalyzed cross-coupling reactions for complex molecule assembly.
• Ligand and Catalyst Development: Utilized in the preparation of novel ligands for catalysis and metal-organic frameworks (MOFs).
• Academic & Industrial R&D: A versatile reagent for exploratory chemistry in both university laboratories and corporate R&D centers.

Basic Information

Product Name	2-Ethynyl-5-Fluoro-Pyrimidine
CAS No.	1204333-35-6
Molecular Formula	C6H3FN2
Molecular Weight	122.10 g/mol
Synonyms	5-Fluoro-2-ethynylpyrimidine; 2-Ethynyl-5-fluoropyrimidine; 5-Fluoro-2-pyrimidineacetylene; 2-Ethynyl-5-fluoro-1,3-diazine; 1204333-35-6
EINECS	Contact for details

Quality Control

Our 2-Ethynyl-5-Fluoro-Pyrimidine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and GC-MS, to ensure high purity and batch-to-batch consistency suitable for sensitive R&D and scale-up processes. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, prolonged exposure to light should be avoided.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.