Description

4-Chloro-5-(4-Iodophenyl)-7H-Pyrrolo[2,3-D]Pyrimidin-2-Amine is a high-purity, heterocyclic organic compound belonging to the pyrrolopyrimidine class, serving as a critical building block in advanced pharmaceutical research and development. Its molecular structure, featuring both chloro and iodo substituents on a fused ring system, makes it a versatile intermediate for constructing targeted kinase inhibitors and other biologically active molecules. This compound is essential for medicinal chemists and R&D teams in the pharmaceutical and biotechnology industries focused on oncology, inflammation, and CNS drug discovery programs.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the development of novel protein kinase inhibitors for therapeutic applications.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization campaigns to explore new chemical entities.
• Biochemical Tool Compound: Serves as a reference standard or a starting point for developing selective enzyme modulators in biological assays.
• API Synthesis: Employed in the multi-step synthesis of potential Active Pharmaceutical Ingredients (APIs) targeting specific disease pathways.
• Contract Research & Development (CRO): Supplied to research organizations for custom synthesis and proprietary drug discovery projects.

Basic Information

Product Name	4-Chloro-5-(4-Iodophenyl)-7H-Pyrrolo[2,3-D]Pyrimidin-2-Amine
CAS No.	1204298-64-5
Molecular Formula	C12H8ClIN4
Molecular Weight	370.57 g/mol
Synonyms	4-Chloro-5-(4-iodophenyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine; 2-Amino-4-chloro-5-(4-iodophenyl)-7H-pyrrolo[2,3-d]pyrimidine; 5-(4-Iodophenyl)-4-chloro-7H-pyrrolo[2,3-d]pyrimidin-2-amine; 1204298-64-5; 4-Chloro-5-(4-iodophenyl)-7H-pyrrolo[2,3-d]pyrimidin-2-ylamine; Pyrrolo[2,3-d]pyrimidine, 4-chloro-5-(4-iodophenyl)-7H-, 2-amino-
EINECS	Contact for details

Quality Control

Every batch of 4-Chloro-5-(4-Iodophenyl)-7H-Pyrrolo[2,3-D]Pyrimidin-2-Amine is manufactured under controlled conditions and undergoes rigorous analytical testing to ensure identity, purity, and consistency. Our quality assurance protocols are designed to meet the stringent requirements of pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing purity (typically ≥95% by HPLC), identity confirmation (by NMR, MS), and impurity profile is provided with each shipment to support your regulatory and research documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept sealed under an inert atmosphere when not in use to prevent degradation and ensure long-term stability.

Specification

Item	Specification
Appearance	Off-white to light yellow solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95.0%
Single Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 5.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.