Description

{1-[5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyrimidin-2-Yl]Piperidin-4-Yl}Methanol is a high-value, functionalized boronic ester derivative, serving as a critical building block in modern synthetic chemistry. Its core value lies in enabling the precise construction of complex molecules through efficient cross-coupling reactions, which are fundamental to pharmaceutical and advanced materials research. This compound is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for developing new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key precursor in Suzuki-Miyaura cross-coupling reactions for synthesizing novel drug candidates, particularly in kinase inhibitor and oncology research.
• Agrochemical Synthesis: Building block for creating advanced active ingredients with improved efficacy and environmental profiles.
• Material Science Research: Used in the development of organic electronic materials, such as OLEDs and organic semiconductors, where the piperidine-pyrimidine core offers tunable electronic properties.
• Chemical Biology & Proteomics: Employed in the synthesis of molecular probes and affinity tags for studying biological targets and pathways.
• Library Synthesis for Drug Discovery: Enables the rapid, parallel synthesis of diverse compound libraries for high-throughput screening in medicinal chemistry.
• Ligand and Catalyst Development: Serves as a sophisticated ligand precursor for transition metal catalysts used in asymmetric synthesis.

Basic Information

Product Name	{1-[5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyrimidin-2-Yl]Piperidin-4-Yl}Methanol
CAS No.	1202805-30-8
Molecular Formula	C16H26BN3O3
Molecular Weight	319.21 g/mol
Synonyms	4-(Hydroxymethyl)-1-[5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidin-2-yl]piperidine; (1-(5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidin-2-yl)piperidin-4-yl)methanol; 2-(4-(Hydroxymethyl)piperidin-1-yl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine; Pinacol [2-(4-(hydroxymethyl)piperidin-1-yl)pyrimidin-5-yl]boronate; Boronic acid, B-[2-[4-(hydroxymethyl)-1-piperidinyl]-5-pyrimidinyl]-, pinacol ester; CAS 1202805-30-8; 1202805-30-8
EINECS	Contact for details

Quality Control

Our {1-[5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyrimidin-2-Yl]Piperidin-4-Yl}Methanol is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, meeting the exacting standards required for research and process chemistry. All products undergo rigorous analytical testing, including HPLC, NMR, and MS, to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which can affect stability and reactivity. For long-term storage, consider using desiccants or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.