Description

2-(4-Hydroxypiperidin-1-Yl)Pyrimidine-5-Boronic Acid Pinacol Ester is a sophisticated boronic ester derivative, a key building block in modern synthetic chemistry. Its primary value lies in enabling efficient Suzuki-Miyaura cross-coupling reactions, a cornerstone method for constructing complex molecules. This high-purity intermediate is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries developing new active ingredients.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel drug candidates, particularly in kinase inhibitor and other small-molecule therapeutic programs.
• Agrochemical Research: Used to construct complex heterocyclic scaffolds for developing new pesticides and herbicides with improved efficacy.
• Material Science: Serves as a building block for creating advanced organic electronic materials and functional polymers.
• Chemical Biology & Proteomics: Employed in the synthesis of molecular probes and activity-based protein profiling (ABPP) reagents.
• Catalyst & Ligand Development: Acts as a precursor for novel ligands used in transition metal catalysis.
• Custom Synthesis & Contract Manufacturing: A vital component for CROs and CDMOs offering bespoke chemical synthesis services.

Basic Information

Product Name	2-(4-Hydroxypiperidin-1-Yl)Pyrimidine-5-Boronic Acid Pinacol Ester
CAS No.	1202805-26-2
Molecular Formula	C15H24BN3O3
Molecular Weight	305.18 g/mol
Synonyms	2-(4-Hydroxypiperidin-1-yl)pyrimidine-5-boronic acid pinacol ester; 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-(4-hydroxypiperidin-1-yl)pyrimidine; 2-(4-Hydroxy-1-piperidinyl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine; 1-(5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidin-2-yl)piperidin-4-ol; B-2-(4-Hydroxy-1-piperidinyl)-5-pyrimidinylboronic acid pinacol ester
EINECS	Contact for details

Quality Control

Our 2-(4-Hydroxypiperidin-1-Yl)Pyrimidine-5-Boronic Acid Pinacol Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and LC-MS, to ensure high purity and consistent performance in sensitive coupling reactions. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) in a cool, dry place at 2-8°C for long-term stability. The compound is easily oxidized and light-sensitive; allow the sealed container to reach room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.