Description

D-Glutamic Acid-13C5 is a stable isotope-labeled analog of the amino acid glutamic acid, where five carbon atoms are replaced with the 13C isotope. This high-purity labeled compound is essential for advanced research requiring precise metabolic pathway tracing and quantitative analysis. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and diagnostic manufacturers for applications in mass spectrometry, NMR spectroscopy, and clinical research.

Application

• Internal Standard for Mass Spectrometry (MS): Serves as a critical quantitative reference standard in LC-MS and GC-MS analysis for accurate measurement of endogenous glutamic acid levels in complex biological matrices.
• Metabolic Flux Analysis (MFA): Used as a tracer to study the dynamics of metabolic networks, including the TCA cycle and amino acid metabolism, in cell cultures, tissues, and whole organisms.
• NMR Spectroscopy Studies: Provides a non-radioactive, stable isotopic label for structural and dynamic studies of proteins, peptides, and metabolic processes using Nuclear Magnetic Resonance.
• Pharmaceutical Drug Development: Employed in pharmacokinetic (PK) and pharmacodynamic (PD) studies to track the metabolism of drug candidates containing glutamic acid moieties.
• Clinical Diagnostics & Biomarker Research: Facilitates the development and validation of assays for disease biomarkers related to glutamate metabolism, such as in neurological disorders.
• Nutritional Science Research: Applied in studies investigating amino acid absorption, protein synthesis, and whole-body nitrogen metabolism using isotopic labeling techniques.

Basic Information

Product Name	D-Glutamic Acid-13C5
CAS No.	1202063-54-4
Molecular Formula	¹³C₅H₉NO₄
Molecular Weight	152.09 (based on ¹³C=13.0034)
Synonyms	(2R)-2-Aminopentanedioic acid-13C5; D-Glu-13C5; (R)-2-Aminoglutaric acid-13C5; D-(-)-Glutamic acid-13C5; (R)-Glutamic acid-13C5; Stable Isotope Labeled D-Glutamate; 13C5-Labeled D-Glutamic Acid
EINECS	Contact for details

Quality Control

Our D-Glutamic Acid-13C5 is manufactured under strict quality systems to ensure the highest isotopic and chemical purity for sensitive research applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing isotopic enrichment (Atom % 13C), chemical purity, and analytical results from techniques such as NMR, MS, and HPLC. We adhere to cGMP principles for production and control, ensuring traceability and consistency for our global clientele in regulated environments.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C in a cool, dry place. This product is hygroscopic (moisture-sensitive). For long-term storage under inert atmosphere, consider sealing under argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment (Atom % 13C)	≥ 99% 13C5
Optical Rotation	[α]20/D: Specific range provided per COA
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.